Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Aminophylline alters the core temperature response to acute hypoxemia in newborn and older guinea pigs
Autore:
Crisanti, KC; Fewell, JE;
Indirizzi:
Univ Calgary, Dept Physiol & Biophys, Hlth Sci Ctr, Calgary, AB T2N 4N1, Canada Univ Calgary Calgary AB Canada T2N 4N1 i Ctr, Calgary, AB T2N 4N1, Canada
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 3, volume: 46, anno: 1999,
pagine: R829 - R835
SICI:
0363-6119(199909)46:3<R829:AATCTR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN ADIPOSE-TISSUE; ADENOSINE CONCENTRATION; POSTNATAL MATURATION; METABOLIC RESPONSES; HYPOXIC HYPOXIA; DENERVATED RATS; COLD; THERMOGENESIS; HYPOTHERMIA; ADIPOCYTES;
Keywords:
adenosine; autonomic thermoregulation; behavioral thermoregulation; postnatal maturation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Fewell, JE Univ Calgary, Dept Physiol & Biophys, Hlth Sci Ctr, Fewell Heritage Med Res Bldg 206,3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada Univ Calgary Fewell Heritage Med Res Bldg 206,3330 Hosp Dr NW Calgary AB Canada T2N4N1
Citazione:
K.C. Crisanti e J.E. Fewell, "Aminophylline alters the core temperature response to acute hypoxemia in newborn and older guinea pigs", AM J P-REG, 46(3), 1999, pp. R829-R835

Abstract

In newborns and adults of a number of species, exposure to acute hypoxemiaproduces a "regulated" decrease in core temperature, the mechanism of which is unknown. The present experiments were carried out on chronically instrumented newborn (5-10 days of age; n = 27) and older (25-30 days of age; n = 23) guinea pigs to test the hypothesis that adenosine mediates this regulated decrease in core temperature. During an experiment, core temperature was measured by biotelemetry from animals studied in a thermocline during a control period of normoxemia, an experimental period of normoxemia or acutehypoxemia (fraction of inspired oxygen 0.10), and during a recovery periodof normoxemia after an intraperitoneal injection of 10 mg/kg aminophylline(i.e., a nonspecific adenosine antagonist) or vehicle. Core temperature decreased significantly during hypoxemia after vehicle in both newborn and older guinea pigs. After aminophylline, however, newborn guinea pigs failed to significantly decrease their core temperature, whereas older guinea pigs exhibited an attenuated yet significant core temperature decrease during hypoxemia. Our data support the hypothesis that adenosine plays an age-dependent role in mediating the regulated decrease in core temperature that occurs in newborn and older guinea pigs during acute hypoxemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:16:16