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Titolo:
Sympathetic control of BP and BP variability in borderline hypertensive rats on high- vs. low-salt diet
Autore:
Brown, DR; Li, SG; Lawler, JE; Randall, DC;
Indirizzi:
Univ Kentucky, Coll Med, Dept Physiol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 ept Physiol, Lexington, KY 40536 USA Univ Kentucky, Coll Med, Ctr Biomed Engn, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 Biomed Engn, Lexington, KY 40536 USA Univ Tennessee, Dept Psychol, Knoxville, TN 37996 USA Univ Tennessee Knoxville TN USA 37996 pt Psychol, Knoxville, TN 37996 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 3, volume: 46, anno: 1999,
pagine: R650 - R657
SICI:
0363-6119(199909)46:3<R650:SCOBAB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL BLOOD-PRESSURE; CARDIOVASCULAR REACTIVITY; STRESS; RESPONSES; SODIUM; BHR; BALANCE;
Keywords:
autonomic nervous system; behavioral stress; classical conditioning; Pavlovian conditioning; sympathetic nerve activity; blood pressure reactivity; borderline hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, DR Univ Kentucky, Coll Med, Dept Physiol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 l, Lexington, KY 40536 USA
Citazione:
D.R. Brown et al., "Sympathetic control of BP and BP variability in borderline hypertensive rats on high- vs. low-salt diet", AM J P-REG, 46(3), 1999, pp. R650-R657

Abstract

This experiment tested the effect of a high-salt diet on the interaction between arterial blood pressure (BP) and sympathetic nerve activity (SNA) atrest and during a controlled behavioral stress at an early stage in the development of hypertension in borderline hypertensive rats (BHR). Ten rats were maintained on a high-salt diet (8% NaCl) while 14 were fed a low-salt diet (0.8% NaCl) for 8 wk. They were trained in a Pavlovian paradigm by following a conditional stimulus tone (CS+) with a 0.5-s shock. SNA and BP weremeasured by implanted electrodes around the left renal nerve and a catheter in the femoral artery, respectively. There were no detectable between-group differences in BP or in BP variability in the resting animal at the end of the 8-wk dietary treatment. Moreover, there were no significant between-group differences in the changes in SNA evoked by the CS+ tone. Conversely,the amplitude of the initial conditional increase in BP was significantly (P < 0.05) larger in the high-salt (6 +/- 0.6 mmHg; mean +/- SEM) compared with the low-salt (4 +/- 0.4 mmHg) group. In addition, the BP excursion (peak/trough) during CS+ was larger in the high (18.2 +/- 6.1 mmHg)- vs. low-salt (5.8 +/- 0.4 mmHg) diet-fed subjects. The ratio of the average percent change in mean BP to the average percent change in SNA at the beginning of CS+ was 0.029 +/- 0.004 for the low-salt group and 0.041 +/- 0.006 for the high-salt group. We find that, before the development of overt hypertension, the enhanced conditional BP response in the high-salt BHR appears to reside at the interface between changes in SNA and the effector response and not within the central nervous system. These observations help explain the increasing BP variability typically observed with the development of hypertension in humans.

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Documento generato il 05/12/20 alle ore 10:08:26