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Titolo:
Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells
Autore:
Segall, L; Lameloise, N; Assimacopoulos-Jeannet, F; Roche, E; Corkey, P; Thumelin, S; Corkey, BE; Prentki, M;
Indirizzi:
CHUM, Ctr Rech, Montreal, PQ H2L 4M1, Canada CHUM Montreal PQ Canada H2L 4M1 M, Ctr Rech, Montreal, PQ H2L 4M1, Canada Univ Montreal, Dept Nutr, Mol Nutr Unit, Montreal, PQ H2L 4M1, Canada UnivMontreal Montreal PQ Canada H2L 4M1 it, Montreal, PQ H2L 4M1, Canada Univ Montreal, Inst Canc Montreal, Montreal, PQ H2L 4M1, Canada Univ Montreal Montreal PQ Canada H2L 4M1 al, Montreal, PQ H2L 4M1, Canada Univ Geneva, Ctr Med, Dept Med Biochem, CH-1211 Geneva, Switzerland Univ Geneva Geneva Switzerland CH-1211 chem, CH-1211 Geneva, Switzerland Boston Univ, Med Ctr, Sch Med, Ctr Obes & Metab, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 d, Ctr Obes & Metab, Boston, MA 02118 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 3, volume: 40, anno: 1999,
pagine: E521 - E528
SICI:
0193-1849(199909)40:3<E521:LRTGMI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM EXPOSURE; CHAIN ACYL-COA; PYRUVATE-DEHYDROGENASE ACTIVITY; CARBOXYLASE GENE-EXPRESSION; PANCREATIC BETA-CELLS; FATTY-ACID OXIDATION; PROTEIN-KINASE-C; MALONYL-COA; LINE INS-1; B-CELL;
Keywords:
fatty acids; insulin secretion; obesity; type 2 diabetes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Prentki, M CHUM, Ctr Rech, Pavillon Seve,4E,1560 Sherbrooke Est, Montreal,PQ H2L 4M1, Canada CHUM Pavillon Seve,4E,1560 Sherbrooke Est Montreal PQ Canada H2L 4M1
Citazione:
L. Segall et al., "Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells", AM J P-ENDO, 40(3), 1999, pp. E521-E528

Abstract

A comprehensive metabolic study was carried out to understand how chronic exposure of pancreatic p-cells to fatty acids causes high basal secretion and impairs glucose-induced insulin release. INS-1 beta-cells were exposed to 0.4 mM oleate for 3 days and subsequently incubated at 5 or 25 mM glucose, after which various parameters were measured. Chronic oleate promoted triglyceride deposition, increased fatty acid oxidation and esterification, and reduced malonyl-CoA at low glucose in association with elevated basal O-2consumption and redox state. Oleate caused a modest (25%) reduction in glucose oxidation but did not affect glucose usage, the glucose 6-phosphate and citrate contents, and the activity of pyruvate dehydrogenase of INS-1 cells. Thus changes in glucose metabolism and a Randle-glucose/fatty acid cycle do not explain the altered secretory properties of beta-cells exposed to fatty acids. The main response of INS-1 cells to chronic oleate, which is to increase the oxidation and esterification of fatty acids, may contribute to cause high basal insulin secretion via increased production of reducing equivalents and/or the generation of complex lipid messenger molecule(s).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 23:57:53