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Titolo:
The effects of adenosine ligands R-PIA and CPT on ethanol withdrawal
Autore:
Gatch, MB; Wallis, CJ; Lal, H;
Indirizzi:
Univ N Texas, Hlth Sci Ctr, Dept Pharmacol, Ft Worth, TX 76107 USA Univ N Texas Ft Worth TX USA 76107 Dept Pharmacol, Ft Worth, TX 76107 USA
Titolo Testata:
ALCOHOL
fascicolo: 1, volume: 19, anno: 1999,
pagine: 9 - 14
SICI:
0741-8329(199908)19:1<9:TEOALR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED MOTOR INCOORDINATION; RAT CEREBELLAR SYNAPTOSOMES; NUCLEOSIDE TRANSPORTER; MICE; TOLERANCE; INTOXICATION; ACTIVATION; DEPENDENCE; RECEPTORS; CAFFEINE;
Keywords:
ethanol-withdrawal; adenosine receptor; R(-)-N-6-(2-phenylisopropyl)adenosine; 8-cyclopentyl-1,3,dimethylxanthine; anxiety; ethanol consumption; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Gatch, MB Univ N Texas, Hlth Sci Ctr, Dept Pharmacol, 3500 Camp Bowie Blvd, Ft Worth, TX 76107 USA Univ N Texas 3500 Camp Bowie Blvd Ft Worth TX USA 76107 6107 USA
Citazione:
M.B. Gatch et al., "The effects of adenosine ligands R-PIA and CPT on ethanol withdrawal", ALCOHOL, 19(1), 1999, pp. 9-14

Abstract

The potential anxiogenic or anxiolytic effects of R(-)-N-6-(2-phenylisopropyl) adenosine (R-PIA), an adenosine agonist, and 8-cyclopentyl-1,3,dimethylxanthine (CPT), an adenosine antagonist, were tested during chronic exposure to ethanol and to ethanol-induced withdrawal in rats. Effects on anxietywere measured by the elevated plus maze and dark-light box. Ethanol consumption and preference was tested in an additional experiment. In testing of elevated plus maze performance during withdrawal from ethanol, R-PIA produced no change in the anxiety-related behaviors of total arm entries and percent open arm entries, but produced a significant decrease in percent open arm time. CPT produced at least partial recovery from the anxiogenic effectsof ethanol withdrawal on all three measures of elevated plus maze performance, although peak effects were seen at the intermediate dose of CPT (0.08 mg/kg) for total arm entries and percent open arm time. CPT also showed anxiolytic effects at low to intermediate doses (0.04, 0.08 mg/kg) in the dark-light box. CPT did not reduce the preference for ethanol over water or thetotal consumption of ethanol over a range of ethanol doses. In summary, the adenosine agonist, R-PIA, exacerbated the effects of ethanol withdrawal, whereas the adenosine antagonist, CPT, at least partially blocked the anxiogenic effects produced by ethanol withdrawal. These results suggest that adenosine antagonists, at least Bt some doses, may be useful for amelioratingthe anxiogenic effects produced by ethanol withdrawal, although it does not appear useful for reducing consumption. (C) 1999 Elsevier Science Inc. All rights reserved.

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Documento generato il 08/08/20 alle ore 00:28:41