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Titolo:
BLOOD-FLOW DYNAMICS, ATHEROSCLEROSIS AND BYPASS GRAFT FAILURE
Autore:
LANGILLE BL; OJHA M;
Indirizzi:
UNIV TORONTO,DEPT PATHOL,TORONTO HOSP,RES INST TORONTO ON CANADA UNIV TORONTO,DEPT OBSTET & GYNECOL,TORONTO HOSP,RES INST TORONTO ON CANADA UNIV TORONTO,INST BIOMED ENGN TORONTO ON M5G 2C4 CANADA
Titolo Testata:
Trends in cardiovascular medicine
fascicolo: 4, volume: 7, anno: 1997,
pagine: 111 - 118
SICI:
1050-1738(1997)7:4<111:BDAABG>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUID SHEAR-STRESS; VASCULAR ENDOTHELIAL-CELLS; SIGNAL-TRANSDUCTION; INTIMAL HYPERPLASIA; CAROTID BIFURCATION; PULSATILE FLOW; ARTERIAL TREE; RABBIT AORTA; LESIONS; PATTERNS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
B.L. Langille e M. Ojha, "BLOOD-FLOW DYNAMICS, ATHEROSCLEROSIS AND BYPASS GRAFT FAILURE", Trends in cardiovascular medicine, 7(4), 1997, pp. 111-118

Abstract

Atherosclerosis occurs at reproducible sites in the arterial tree andintimal proliferation that leads to bypass gl aft occlusion also showa well-defined focal distribution These observations have led to the hypothesis that local blood flow conditions, especially low or fluctuating shear stresses, are important in the development of both disorders. Basic research using both cell culture and animal models has revealed that endothelial cell biology is very sensitive to local shear stresses and rapid progress is being made in characterizing how endothelial cells transduce shear stress. Endothelial sensitivity to shear stress affects control of hemostasis, leukocyte adherence and transmigration, growth factor production, vasomotor responses, endothelial repair and arterial wall remodeling, all of which can be expected to influencedevelopment of vascular pathologies. Also, substantial progress has been made in characterizing complex local hemodynamics at relevant arterial sites, however, further progress is needed in this area, as well as in the extrapolation of advances in basic vascular biology to humanvascular disease. (C) 1997, Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:36:16