Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cytotoxicity and membrane interaction of tamoxifen as affected by Ca2+ andMg2+: Use of a bacterial model system
Autore:
Luxo, C; Jurado, AS; Madeira, VMC;
Indirizzi:
Univ Coimbra, Fac Farm, Microbiol Lab, P-3000 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3000 obiol Lab, P-3000 Coimbra, Portugal Univ Coimbra, Ctr Neurociencias, P-3000 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3000 ociencias, P-3000 Coimbra, Portugal
Titolo Testata:
TOXICOLOGY IN VITRO
fascicolo: 4-5, volume: 13, anno: 1999,
pagine: 587 - 590
SICI:
0887-2333(199908/10)13:4-5<587:CAMIOT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BACILLUS-STEAROTHERMOPHILUS; PHYSICAL-PROPERTIES; MECHANISMS; CALCIUM; TRANSDUCTION; TOXICITY; LIPIDS;
Keywords:
calcium; magnesium; tamoxifen; Bacillus stearothermophilus; bacterial growth; membrane physical effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Luxo, C Univ Coimbra, Fac Farm, Microbiol Lab, P-3000 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3000 b, P-3000 Coimbra, Portugal
Citazione:
C. Luxo et al., "Cytotoxicity and membrane interaction of tamoxifen as affected by Ca2+ andMg2+: Use of a bacterial model system", TOX VITRO, 13(4-5), 1999, pp. 587-590

Abstract

A strain of Bacillus stearothermophilus was used as a model to study the interaction of tamoxifen (TAM) with the membrane and the cytostatic antiproliferative effects not related to estrogen binding. TAM inhibits the growth of B. stearothermophilus as a function of concentration. The supplementation of the growth medium with Ca2+ or Mg2+ partially relieves the growth inhibition by TAM, allowing growth at TAM concentrations thar fully impair growth in the basal medium. Fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene (DPH) and of its propionic acid derivative (DPH-PA) reveals opposite effects induced by TAM and Ca2+. The addition of Ca2+ to liposomes of bacterial lipids promoted physical ordering as opposed to disordering induced by TAM. Thus, it is predictable that growth impairment induced by TAM is mediated through perturbations at the membrane level. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 10:49:37