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Titolo:
Brachytherapy for the prevention of stenosis in a canine hemodialysis graft model: Preliminary observations
Autore:
Trerotola, SO; Carmody, TJ; Timmerman, RD; Bergan, KA; Dreesen, RG; Frost, SV; Forney, M;
Indirizzi:
Indiana Univ, Med Ctr, Dept Radiol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 Radiol, Indianapolis, IN 46202 USA Indiana Univ, Med Ctr, Dept Radiat Oncol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 Oncol, Indianapolis, IN 46202 USA Indiana Univ, Med Ctr, Dept Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 pt Med, Indianapolis, IN 46202 USA Indiana Univ, Med Ctr, Dept Surg, Indianapolis, IN 46202 USA Indiana UnivIndianapolis IN USA 46202 t Surg, Indianapolis, IN 46202 USA
Titolo Testata:
RADIOLOGY
fascicolo: 3, volume: 212, anno: 1999,
pagine: 748 - 754
SICI:
0033-8419(199909)212:3<748:BFTPOS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBITS NEOINTIMA FORMATION; INTIMAL-MEDIAL HYPERPLASIA; ARTERIOVENOUS LOOP GRAFTS; MUSCLE CELL-PROLIFERATION; DIALYSIS ACCESS GRAFTS; ARTERY BALLOON INJURY; LOW-DOSE IRRADIATION; STENT IMPLANTATION; RADIATION-THERAPY; VENOUS ANASTOMOSIS;
Keywords:
animals; dialysis, shunts; grafts, interventional procedures; grafts, stenosis or thrombosis; iridium, radioactive;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Trerotola, SO Indiana Univ, Med Ctr, Dept Radiol, UH0279,550 N Univ Blvd, Indianapolis, IN 46202 USA Indiana Univ UH0279,550 N Univ Blvd IndianapolisIN USA 46202
Citazione:
S.O. Trerotola et al., "Brachytherapy for the prevention of stenosis in a canine hemodialysis graft model: Preliminary observations", RADIOLOGY, 212(3), 1999, pp. 748-754

Abstract

PURPOSE: To determine whether gamma brachytherapy can prevent in-stent stenosis in hemodialysis grafts. MATERIALS AND METHODS: Six-millimeter polytetrafluoroethylene arteriovenous grafts were created bilaterally in six dogs. After 1 month, Wallstents spanning the venous anastomosis were placed to accelerate restenosis. Gamma irradiation (12 Gy) was delivered endoluminally to one of the two grafts by using an iridium 192 source; -thus, each animal served as its own control. Fistulography was performed monthly for 10 months or until graft thrombosis, with measurement of stenosis at each time point. At the conclusion of thestudy period, the treated area was examined histologically, and a computermodel was used to calculate the volume of intimal hyperplasia. RESULTS: Delayed stent migration resulted in exclusion of one dog. In the remaining five dogs, maximum stenosis across all time intervals was less for the treated side (P <.04), and the volume of intimal hyperplasia was lessfor the treated ride (P <.045). In one animal studied at 1 year, this trend reversed in terms of percentage stenosis but not total neointimal volume. CONCLUSION: Brachytherapy with (192)lr (gamma) delivered at the time of stent placement reduces restenosis in-this hemodialysis graft model, but, depending on the parameter evaluated (stenosis vs total volume of neointima), the benefit may wane or even reverse with time.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 12:29:39