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Titolo:
Hepatic intraarterial I-131 iodized oil for treatment of hepatocellular carcinoma in patients with impeded portal venous flow
Autore:
de Baere, T; Taourel, P; Tubiana, JM; Kuoch, V; Ducreux, M; Lumbroso, J; Roche, AJ;
Indirizzi:
Inst Gustave Roussy, Dept Intervent Radiol, F-94805 Villejuif, France InstGustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France Inst Gustave Roussy, Dept Med, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France Inst Gustave Roussy, Dept Nucl Med, F-94805 Villejuif, France Inst GustaveRoussy Villejuif France F-94805 , F-94805 Villejuif, France St Eloi Hosp, Dept Med Imaging, Montpellier, France St Eloi Hosp Montpellier France , Dept Med Imaging, Montpellier, France Hop St Antoine, Dept Med Imaging, F-75571 Paris, France Hop St Antoine Paris France F-75571 t Med Imaging, F-75571 Paris, France
Titolo Testata:
RADIOLOGY
fascicolo: 3, volume: 212, anno: 1999,
pagine: 665 - 668
SICI:
0033-8419(199909)212:3<665:HIIIOF>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERNAL RADIATION-THERAPY; NATURAL-HISTORY; ARTERIAL INJECTION; PROGNOSTIC FACTORS; LIPIODOL; CHEMOEMBOLIZATION; LIVER; BIODISTRIBUTION; TUMORS; TRIAL;
Keywords:
hepatic arteries, therapeutic blockade; iodine and iodine compounds, radioactive; liver neoplasms, chemotherapeutic infusion; portal vein, stenosis or obstruction; radionuclides, therapeutic; therapeutic radiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: de Baere, T Inst Gustave Roussy, Dept Intervent Radiol, Rue Camille Desmoulins, F-94805 Villejuif, France Inst Gustave Roussy Rue Camille Desmoulins Villejuif France F-94805
Citazione:
T. de Baere et al., "Hepatic intraarterial I-131 iodized oil for treatment of hepatocellular carcinoma in patients with impeded portal venous flow", RADIOLOGY, 212(3), 1999, pp. 665-668

Abstract

PURPOSE: To evaluate the efficacy and safety of intraarterial hepatic iodine 131 iodized ii for treatment of hepatocellular carcinoma in patients with impeded portal venous flow. MATERIALS AND METHODS: Twenty-four patients (mean age, 61 years) with hepatocellular carcinoma underwent 38 courses of I-131 iodized oil tone to three per patient), with a mean dose of 2,146 MBq injected into the proper hepatic artery. Hepatocellular carcinoma manifested as single nodules (n = 8; mean, 7.75 cm), multiple nodules (n = 13; mean, 5.46 cm), or a mass (n = 3) occupying more than two hepatic segments. Portal venous thrombosis was complete (n = 10), right (n =),left (n = 2),:or multisegmental(n = 1). Two patients had hepatofugal portal flow. RESULTS: Among the 23 patients with evaluatable results, response to treatment was partial in three, and disease was stable in 12 and progressive in eight. Estimated actuarial survival rates were 70%, 33%, 12%, and 6% at 3, 6, 9, and 12 months, respectively, with two patients alive at 9 and 11 months. The median survival time was 147 days: Adverse events were the early death of one patient owing to hepatic failure and transient symptomatic hepatic failure after 12 courses in nine patients. CONCLUSION: In this preliminary experience, intraarterial hepatic I-131 iodized oil did not demonstrate high efficacy in the treatment of hepatocellular carcinoma in patients with portal venous thrombosis, as side effects were not rare.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 04:59:25