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Titolo:
Association analysis between dopamine receptor genes and bipolar affectivedisorder
Autore:
Li, T; Liu, XH; Sham, PC; Aitchison, KJ; Cai, GQ; Arranz, MJ; Deng, H; Liu, J; Kirov, G; Murray, RM; Collier, DA;
Indirizzi:
Inst Psychiat, Dept Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England W China Univ Med Sci, Dept Psychiat, Chengdu 610041, Sichuan, Peoples R China W China Univ Med Sci Chengdu Sichuan Peoples R China 610041 oples R China Univ Wales, Coll Med, Dept Psychol Med, Cardiff CF4 4XN, S Glam, Wales Univ Wales Cardiff S Glam Wales CF4 4XN d, Cardiff CF4 4XN, S Glam, Wales
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 3, volume: 86, anno: 1999,
pagine: 193 - 201
SICI:
0165-1781(19990630)86:3<193:AABDRG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL POLYMORPHISM; PROMOTER REGION; NO ASSOCIATION; D4 RECEPTOR; D2; SCHIZOPHRENIA; TRANSMISSION; TRANSPORTER; CRITERIA; SCHEDULE;
Keywords:
neurotransmitter receptors; genetics; psychosis; DRD2; DRD3; DRD4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Li, T Inst Psychiat, Dept Psychol Med, De Crespigny Pk,Denmark Hill, London SE5 8AF, England Inst Psychiat De Crespigny Pk,Denmark Hill London England SE5 8AF d
Citazione:
T. Li et al., "Association analysis between dopamine receptor genes and bipolar affectivedisorder", PSYCHIAT R, 86(3), 1999, pp. 193-201

Abstract

We have performed a case-control analysis of dopamine D2-like receptor (DRD2 DRD3 and DRD4) gene polymorphisms in 118 Han Chinese cases with bipolar affective disorder and 196 control subjects, and replication analysis in 157 English cases and 143 control subjects. We, found association between a functional DRD2 promoter variant (P = 0.03 by allele) and the DRD2 taq1A polymorphism (P = 0.001 by allele) in Chinese bipolar disorder patients. However, this finding was not replicated in the Caucasian subjects, indicating that the significant association we observed in the Chinese population is a false positive finding. An alternative explanation is that these polymorphisms are risk factors in Chinese but not Caucasian populations, a hypothesiswhich seems unlikely in view of the similarity of the clinical characteristics of bipolar disorder in the two populations. We also report a novel, rare one-repeat variant of the DRD4 exon 3 VNTR repeat in Chinese populations, which appears to be absent in Caucasians and is not associated with disease. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:21:47