Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Differential expression of NGF receptors in human thymic epithelial tumors
Autore:
Parrens, M; Dubus, P; Groppi, A; Velly, JF; Labouyrie, E; de Mascarel, A; Merlio, JP;
Indirizzi:
CHU Bordeaux, Serv Anat Pathol, Lab Histol Embryol, Bordeaux, France CHU Bordeaux Bordeaux France thol, Lab Histol Embryol, Bordeaux, France Univ Bordeaux, Bordeaux, France Univ Bordeaux Bordeaux FranceUniv Bordeaux, Bordeaux, France CHU Bordeaux, Hop Haut Leveque, Serv Chirurg Thorac, Bordeaux, France CHU Bordeaux Bordeaux France que, Serv Chirurg Thorac, Bordeaux, France
Titolo Testata:
PATHOLOGY RESEARCH AND PRACTICE
fascicolo: 8, volume: 195, anno: 1999,
pagine: 549 - 553
SICI:
0344-0338(1999)195:8<549:DEONRI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; TRK PROTOONCOGENE PRODUCT; NEUROTROPHIN RECEPTORS; KINASE; LOCALIZATION; LYMPHOCYTES; PROTEIN; TISSUES; CELLS;
Keywords:
p75(NGFR); Trk, nerve growth factor; thymus; thymomas;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Parrens, M Univ Bordeaux 2, Lab Histol Embryol, UFR 3, EA 2406, 146 Rue Leo-Saignat, F-33076 Bordeaux, France Univ Bordeaux 2 146 Rue Leo-Saignat Bordeaux France F-33076 ce
Citazione:
M. Parrens et al., "Differential expression of NGF receptors in human thymic epithelial tumors", PATH RES PR, 195(8), 1999, pp. 549-553

Abstract

NGF receptor (TrkA and p75(NGFR)) expression was investigated in human thymuses, including normal thymuses, thymic hyperplasias, thymomas and thymic carcinomas. TrkAI but not TrkAII transcripts were demonstrated by RT-PCR. In normal thymuses, immunohistochemistry revealed a restricted TrkA-immunoreactivity to epithelial and interdigitated reticular cells, while only interdigitaded reticular cells were immunoreactive for p75(NGFR). Thymocytes were negative for both receptors. A switch from the normal TrkA positive-p75(NGFR) negative phenotype to a TrkA negative-p75(NGFR) positive phenotype wasfound in histologically aggressive epithelial cell tumors, suggesting thatNGF and its receptors are potentially involved in thymus stroma organogenesis and proliferation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 17:44:05