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Titolo:
SYNTHESIS AND ORAL EFFICACY OF A 4-(BUTYLETHYLAMINO)PYRROLO[2,3-D]PYRIMIDINE - A CENTRALLY ACTIVE CORTICOTROPIN-RELEASING FACTOR(1) RECEPTOR ANTAGONIST
Autore:
CHEN YL; MANSBACH RS; WINTER SM; BROOKS E; COLLINS J; CORMAN ML; DUNAISKIS AR; FARACI WS; GALLASCHUN RJ; SCHMIDT A; SCHULZ DW;
Indirizzi:
PFIZER INC,DIV CENT RES,DEPT MED CHEM GROTON CT 06340 PFIZER INC,DIV CENT RES,DEPT NEUROSCI GROTON CT 06340
Titolo Testata:
Journal of medicinal chemistry
fascicolo: 11, volume: 40, anno: 1997,
pagine: 1749 - 1754
SICI:
0022-2623(1997)40:11<1749:SAOEOA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
Y.L. Chen et al., "SYNTHESIS AND ORAL EFFICACY OF A 4-(BUTYLETHYLAMINO)PYRROLO[2,3-D]PYRIMIDINE - A CENTRALLY ACTIVE CORTICOTROPIN-RELEASING FACTOR(1) RECEPTOR ANTAGONIST", Journal of medicinal chemistry, 40(11), 1997, pp. 1749-1754

Abstract

The syntheses of a centrally active nonpeptide CRF1 receptor antagonist 2, ethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amine (CP-154,526),and its analogs 11-14 and [H-3]-2 are reported. The in vitro CRF1 receptor binding affinity in the series 2, the pharmacokinetic propertiesof 2 in rats, and the anxiolytic-like effects of orally administered 2 are presented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:19:30