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Titolo:
Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial
Autore:
Rembacken, BJ; Snelling, AM; Hawkey, PM; Chalmers, DM; Axon, ATR;
Indirizzi:
Gen Infirm, Ctr Digest Dis, Leeds LS1 3EX, W Yorkshire, England Gen Infirm Leeds W Yorkshire England LS1 3EX S1 3EX, W Yorkshire, England Univ Leeds, Dept Microbiol, Leeds LS2 9JT, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS2 9JT S2 9JT, W Yorkshire, England
Titolo Testata:
LANCET
fascicolo: 9179, volume: 354, anno: 1999,
pagine: 635 - 639
SICI:
0140-6736(19990821)354:9179<635:NECVMF>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; 5-AMINOSALICYLIC ACID MESALAZINE; MAINTENANCE TREATMENT; DOUBLE-BLIND; SULFASALAZINE; OLSALAZINE; REMISSION; EFFICACY; STRAINS; SAFETY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Rembacken, BJ Gen Infirm, Ctr Digest Dis, Great George St, Leeds LS1 3EX, W Yorkshire, England Gen Infirm Great George St Leeds W Yorkshire England LS1 3EX
Citazione:
B.J. Rembacken et al., "Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial", LANCET, 354(9179), 1999, pp. 635-639

Abstract

Background Ulcerative colitis has been suggested to be caused by infectionand there is circumstantial evidence linking Escherichia coli with the condition. Our aim was to find out whether the administration of a non-pathogenic strain of E coli (Nissle 1917) was as effective as mesalazine in preventing relapse of ulcerative colitis. We also examined whether the addition of E coli to standard medical therapy increased the chance of remission of active ulcerative colitis. Methods This was a single-centre, randomised, double dummy study in which 120 patients with active ulcerative colitis were invited to take part. 116 patients accepted; 59 were randomised to mesalazine and 57 to E coli. Atl patients also received standard medical therapy together with a 1-week course of oral gentamicin. After remission, patients were maintained on either mesalazine or E coli and followed up for a maximum of 12 months. A two-stage, conditional, intention-to-treat analysis was done. Findings 44 (75%) patients in the mesalazine group attained remission compared with 39 (68%) in the E coil group. Mean time to remission was 44 days (median 42) in the mesalazine group and 42 days (median 37) for those treated with E coli. In the mesalazine group, 32 (73%) patients relapsed compared with 26 (67%) in the E coli group. Mean duration of remission was 206 days in the mesalazine group (median 175) and 221 days (median 185) in the E coli group. Interpretation Our results suggest that treatment with a nonpathogenic E coli has an equivalent effect to mesalazine in maintaining remission of ulcerative colitis. The beneficial effect of live E coli may provide clues to the cause of ulcerative colitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:25:20