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Titolo:
Differential susceptibility of two species of macaques to experimental vaginal candidiasis
Autore:
Steele, C; Ratterree, M; Fidel, PL;
Indirizzi:
Louisiana State Univ, Med Ctr, Dept Microbiol Immunol & Parasitol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA Tulane Reg Primate Res Ctr, Dept Vet Sci, Covington, LA USA Tulane Reg Primate Res Ctr Covington LA USA t Vet Sci, Covington, LA USA
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 3, volume: 180, anno: 1999,
pagine: 802 - 810
SICI:
0022-1899(199909)180:3<802:DSOTSO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-MEDIATED-IMMUNITY; LYMPHOCYTE SUBSETS; CANDIDAL VAGINITIS; MURINE CANDIDIASIS; LANGERHANS CELLS; ALBICANS; INFECTION; MICE; RECURRENT; RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Fidel, PL Louisiana State Univ, Med Ctr, Dept Microbiol Immunol & Parasitol, 1901 Perdido St, New Orleans, LA 70112 USA Louisiana State Univ 1901 Perdido St New Orleans LA USA 70112 SA
Citazione:
C. Steele et al., "Differential susceptibility of two species of macaques to experimental vaginal candidiasis", J INFEC DIS, 180(3), 1999, pp. 802-810

Abstract

Vulvovaginal candidiasis (VVC) caused by Candida albicans is a significantproblem in women of childbearing age. Unfortunately, protective host defense mechanisms against VVC are poorly understood. Although rodent models of experimental vaginal candidiasis have been useful, several differences fromhumans limit the correlation of experimental data. The purpose of the present study was to examine two species of macaques as an alternative model ofexperimental vaginitis. Screening of pig-tailed and rhesus macaques demonstrated that each had mucosal Candida colonization and prior immune sensitization to C, albicans. Vaginal-associated immunity (cytokines, antibodies, and innate resistance) was also detected in cervicovaginal lavage fluid fromboth species. Nevertheless, intravaginal inoculation of C. albicans into both species, either untreated or under estrogen-treated conditions, resulted in vaginal infection in rhesus, but not pig-tailed, macaques. Several estrogen-dependent changes in the rhesus immune status coincided with susceptibility to infection. Taken together, these results suggest that pig-tailed and rhesus macaques may be useful in studying pathogenesis and immunity associated with C. albicans vaginitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:32:22