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Titolo:
Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes
Autore:
Ikegawa, S; Isomura, M; Koshizuka, Y; Nakamura, Y;
Indirizzi:
Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Genome Med, Tokyo 1088639,Japan Univ Tokyo Tokyo Japan 1088639 nome, Lab Genome Med, Tokyo 1088639,Japan Univ Tokyo, Fac Med, Dept Orthopaed Surg, Tokyo 113, Japan Univ Tokyo Tokyo Japan 113 ac Med, Dept Orthopaed Surg, Tokyo 113, Japan
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 5, volume: 44, anno: 1999,
pagine: 337 - 342
SICI:
1434-5161(1999)44:5<337:CACOHA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEQUENCE; PROTEIN; REGION;
Keywords:
cloning; mapping; PROSC gene; large-scale DNA sequencing; in silico gene trapping;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Ikegawa, S Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Genome Med, 4-6-1 Shirokanedai, Tokyo 1088639, Japan Univ Tokyo 4-6-1 Shirokanedai Tokyo Japan 1088639 88639, Japan
Citazione:
S. Ikegawa et al., "Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes", J HUM GENET, 44(5), 1999, pp. 337-342

Abstract

Large-scale DNA sequencing, coupled with in silico gene trapping, is a robust approach to identifying unknown genes in selected genomic regions. Using this approach we have isolated a novel human gene, PROSC (for proline synthetase co-transcribed [bacterial homolog]), from human chromosome 8p11.2, and its mouse counterpart. The human PROSC gene spanned 17kb of genomic DNA; its cDNA was 2530bp long, with 8 exons that included an open reading frame of 825 bp (275 amino acids). The mouse cDNA (Prosc), 1995 bp long, was predicted to encode 274 amino acids. PROSC is ubiquitously expressed in humantissues and has been highly conserved among divergent species from bacteria to mammals, suggesting its important cellular function. The gene product is likely to be a soluble cytoplasmic protein, but its function remains to be determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 07:05:32