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Titolo:
New ether-a-go-go K+ channel family members localized in human telencephalon
Autore:
Miyake, A; Mochizuki, S; Yokoi, H; Kohda, M; Furuichi, K;
Indirizzi:
Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Mol Med Labs, Ibaraki, Osaka 3058585, Japan Yamanouchi Pharmaceut Co Ltd Ibaraki Osaka Japan 3058585 a 3058585, Japan
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 35, volume: 274, anno: 1999,
pagine: 25018 - 25025
SICI:
0021-9258(19990827)274:35<25018:NEKCFM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTASSIUM CHANNEL; FUNCTIONAL EXPRESSION; GENE; DROSOPHILA; CLONING; MUTATIONS; CELLS; LOCUS; EAG; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Miyake, A Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Mol Med Labs, 21 Miyukigaoka, Ibaraki, Osaka 3058585, Japan Yamanouchi Pharmaceut CoLtd 21 Miyukigaoka Ibaraki Osaka Japan 3058585
Citazione:
A. Miyake et al., "New ether-a-go-go K+ channel family members localized in human telencephalon", J BIOL CHEM, 274(35), 1999, pp. 25018-25025

Abstract

A cDNA encoding a novel voltage-gated K+ channel protein was isolated fromhuman brain. This protein, termed BEC1, is 46% identical to rat elk in theether-a-go-go K+ channel family. The BEC1 gene maps to the 12q13 region ofthe human genome. Northern blot analysis indicates that BEC1 is exclusively expressed in human brain, where the expression is concentrated in the telencephalic areas such as the cerebral cortex, amygdala, hippocampus, and striatum, By in situ hybridization, BEC1 is detected in the CA1-CA3 pyramidalcell layers and the dentate gyrus granule cell layers of the hippocampus. Specific signals are also found in neocortical neurons. Transfection of mammalian L929 and Chinese hamster ovary cells with BEC1 cDNA induces a voltage-gated outward current with a fast inactivation component. This current isinsensitive to tetraethylammonium and quinidine, Additionally, a second related gene BEC2 was isolated from human brain. BEC2 is also brain specific,located in the neocortex and the striatum, and functional as a channel gene. Phylogenetic analysis indicates that BEC1 and BEC2 constitute a subfamily, together with elh, in the ether-a-go-go family. The two genes may be involved in cellular excitability of restricted neurons in the human central nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:26:59