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Titolo:
SYSTEMIC INFLAMMATORY RESPONSES TO EXTRAC ORPOREAL THERAPEUTIC MEASURES .2. CARDIOPULMONARY BYPASS
Autore:
PRONDZINSKY R; MULLERWERDAN U; PILZ G; WITTHAUT R; STABENOW I; WERDAN K; ZERKOWSKI HR;
Indirizzi:
UNIV HALLE WITTENBERG,KLINIKUM KROLLWITZ,LEHRSTUHL KARDIOL INTENS MEDD-06097 HALLE GERMANY UNIV HALLE WITTENBERG,KLIN & POLIKLIN INNERE MED 3 HALLE GERMANY UNIV MUNICH,KLINIKUM GROSSHADERN,MED KLIN & POLIKLIN 1 D-8000 MUNICH GERMANY UNIV HALLE WITTENBERG,KLIN & POLIKLIN HERZ & THORAXCHIRURG HALLE GERMANY
Titolo Testata:
Wiener Klinische Wochenschrift
fascicolo: 10, volume: 109, anno: 1997,
pagine: 346 - 353
SICI:
0043-5325(1997)109:10<346:SIRTEO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
GER
Soggetto:
TUMOR-NECROSIS-FACTOR; CARDIAC-SURGERY; COMPLEMENT ACTIVATION; LEUKOCYTE ACTIVATION; PEDIATRIC-PATIENTS; ORGAN FAILURE; HEART; CYTOKINES; SEPSIS; REPERFUSION;
Keywords:
CARDIOPULMONARY BYPASS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; CYTOKINES; TUMOR NECROSIS FACTOR-ALPHA; SOLUBLE TUMOR NECROSIS FACTOR RECEPTORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
R. Prondzinsky et al., "SYSTEMIC INFLAMMATORY RESPONSES TO EXTRAC ORPOREAL THERAPEUTIC MEASURES .2. CARDIOPULMONARY BYPASS", Wiener Klinische Wochenschrift, 109(10), 1997, pp. 346-353

Abstract

About 65,000 cardiac patients undergo surgery annually in Germany with the assistance of cardiopulmonary bypass. The ''post pump inflammatory response'' (the systemic and myocardial inflammatory response syndrome post cardiac surgery), triggered at least in part by the cardiopulmonary bypass, contributes substantially towards morbidity (e.g., myocardial depression) and mortality in these patients. The main mechanisms underlying this inflammatory response are the complement cascade, the activation of blood cells, the release of cytokines and the induction of nitric oxide synthesis. The relative importance of each individual factor, however, is still a matter of debate. Scoring systems and measurements of tumor necrosis factor-alpha, as well as soluble tumor necrosis factor receptors, allow the early detection of an ''escalating inflammatory response'' in 2-10% of all patients, which is associated with a worse prognosis. Therapeutic attempts to suppress these systemic and myocardial inflammatory reactions focus on blockade of the complement system, coating of CPB membranes with heparin, leucocyte depletion and attenuation of leucocyte function, elimination of toxins and mediators by means of hemofiltration, as well as on the administration of antiproteases, antioxidants, oxygen radical scavengers and also of immune globulins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 12:18:14