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Titolo:
Haloperidol increases spreading and nitric oxide production in macrophagesfrom tumor-bearing mice: a possible mechanism for its antitumoral effect
Autore:
Kleeb, SR; Rizzo, MD; Dagli, MLZ; Frussa, R;
Indirizzi:
Univ Fed Sao Paulo, Dept Farmacol, BR-04023062 Sao Paulo, Brazil Univ Fed Sao Paulo Sao Paulo Brazil BR-04023062 BC3062 Sao Paulo, Brazil Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Patol, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil ootecnia, Dept Patol, Sao Paulo, Brazil
Titolo Testata:
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY
fascicolo: 9, volume: 21, anno: 1999,
pagine: 575 - 580
SICI:
0192-0561(199909)21:9<575:HISANO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERITONEAL-MACROPHAGES; INHIBITION; PROLACTIN; SYNTHASE; RELEASE;
Keywords:
haloperidol; Ehrlich adenocarcinoma; macrophage; nitric oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Frussa, R Univ Fed Sao Paulo, Dept Farmacol, Rua Botucatu 862,Edificio Leal Prado, BR-04023062 Sao Paulo, Brazil Univ Fed Sao Paulo Rua Botucatu 862,Edificio Leal Prado Sao Paulo Brazil BR-04023062 BC
Citazione:
S.R. Kleeb et al., "Haloperidol increases spreading and nitric oxide production in macrophagesfrom tumor-bearing mice: a possible mechanism for its antitumoral effect", INT J IMMUN, 21(9), 1999, pp. 575-580

Abstract

Subcutaneous treatment with haloperidol (2.0 mg/kg) was found to increase both the percent of macrophage spreading and nitric oxide (NO) release in peritoneal macrophage from animals inoculated intraperitoneally with 5.0 x 10(6) Ehrlich ascites cells. This haloperidol-induced macrophage activation seems to be involved in its antitumoral effect since cotreatment with the iNOS inhibitor aminoguanidine was able to reverse the inhibitory effect of haloperidol on the development of the Ehrlich solid carcinoma. (C) 1999 International Society for Immunopharmacology, Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/05/20 alle ore 13:41:58