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Titolo:
Cellular responses to FMLP challenging: A mini-review
Autore:
Panaro, MA; Mitolo, V;
Indirizzi:
Univ Bari, Dept Human Anat, Bari, Italy Univ Bari Bari ItalyUniv Bari, Dept Human Anat, Bari, Italy Policlin, I-70124 Bari, Italy Policlin Bari Italy I-70124Policlin, I-70124 Bari, Italy
Titolo Testata:
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
fascicolo: 3, volume: 21, anno: 1999,
pagine: 397 - 419
SICI:
0892-3973(1999)21:3<397:CRTFCA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORMYL PEPTIDE-RECEPTOR; HUMAN POLYMORPHONUCLEAR LEUKOCYTES; METHIONYL-LEUCYL-PHENYLALANINE; MEDIATED SIGNAL TRANSDUCTION; C5A CHEMOATTRACTANT RECEPTORS; NUCLEOTIDE REGULATORY PROTEIN; INDUCED ACTIN POLYMERIZATION; ADHERENT HUMAN-NEUTROPHILS; RESPIRATORY BURST OXIDASE; ISLET-ACTIVATING PROTEIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
114
Recensione:
Indirizzi per estratti:
Indirizzo: Panaro, MA Univ Bari, Dept Human Anat, Bari, Italy Univ Bari Bari ItalyUniv Bari, Dept Human Anat, Bari, Italy
Citazione:
M.A. Panaro e V. Mitolo, "Cellular responses to FMLP challenging: A mini-review", IMMUNOPH IM, 21(3), 1999, pp. 397-419

Abstract

FMLP (N-formyl-methionyl-leucyl-phenylalanin and other N-formylpeptides are powerful "activators" of polymorphonuclear and mononuclear phagocytes, but they are also active on other cell types. Present knowledge about formylpeptide receptors and the relevant tools for their imaging and the study of their dynamics am briefly discussed. The main responses elicited by FMLP ingranulocytes are cell polarisation, the generation of reactive oxygen species, the production of arachidonic acid metabolites, and the release of lysosomal enzymes. The transduction cascades involved and the agents able to modulate these responses are reviewed. Homologous desensitization and heterologous desensitization of the FMLP-receptor following ligation of other chemokine receptors are also outlined. Finally, the receptor expression and the pharmacological and toxic actions of FMLP upon other tissues and organs, and its actions on the developing embryo, are illustrated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 11:16:29