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Titolo:
The effects of short term lipid infusion on plasma and hepatic bile lipidsin humans
Autore:
Pakula, R; Konikoff, FM; Moser, AM; Greif, F; Tietz, A; Gilat, T; Rubin, M;
Indirizzi:
Beilinson Med Ctr, Dept Surg B, Felsenstein Res Ctr, IL-49100 Petah Tiqwa,Israel Beilinson Med Ctr Petah Tiqwa Israel IL-49100 L-49100 Petah Tiqwa,Israel Tel Aviv Med Ctr, Dept Gastroenterol, Tel Aviv, Israel Tel Aviv Med Ctr Tel Aviv Israel , Dept Gastroenterol, Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Dept Neurobiochem, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 iochem, IL-69978 Tel Aviv, Israel
Titolo Testata:
GUT
fascicolo: 3, volume: 45, anno: 1999,
pagine: 453 - 458
SICI:
0017-5749(199909)45:3<453:TEOSTL>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; TOTAL PARENTERAL-NUTRITION; ENTEROHEPATIC CIRCULATION; CHOLESTEROL-METABOLISM; GALLBLADDER-DISEASE; LIVER; CHOLECYSTECTOMY; CHOLESTYRAMINE; LITHOGENICITY; PHOSPHOLIPIDS;
Keywords:
lipid emulsion; long chain triglycerides; medium chain triglycerides; bile; cholesterol; gallstones;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Rubin, M Beilinson Med Ctr, Dept Surg B, Felsenstein Res Ctr, IL-49100 Petah Tiqwa,Israel Beilinson Med Ctr Petah Tiqwa Israel IL-49100 etah Tiqwa,Israel
Citazione:
R. Pakula et al., "The effects of short term lipid infusion on plasma and hepatic bile lipidsin humans", GUT, 45(3), 1999, pp. 453-458

Abstract

Background-Patients on parenteral nutrition have an increased incidence ofgall bladder sludge and gallstone disease, thought to be related to bile stasis. Intravenous lipid emulsions, especially those containing medium chain triglycerides, have also been shown to have a lithogenic effect on the composition of bile in the gall bladder. Aims-To determine whether lipid infusion influences hepatic bile composition in patients with an indwelling T tube following cholecystectomy and choledochotomy. Methods-In eight patients undergoing the above surgical procedure, the time at which effects of the interrupted enterohepatic circulation were minimal was determined. Twenty two cholesterol gallstone patients with bile fistula were then randomised to receive an infusion of a lipid emulsion containing either long chain triglycerides or a mixture of long and medium chain triglycerides. Results-Lipid infusion resulted in a significant increase in plasma levelsof triglycerides and phospholipids. Both lipid emulsions caused an increase in hepatic biliary cholesterol level and cholesterol saturation index, but this effect was more pronounced with medium chain triglycerides. The fatty acid composition of biliary phospholipids showed a significant enrichmentof linoleic acid by both lipid infusions. Conclusions-Infusion of triglycerides causes lithogenic changes in hepaticbile composition in humans, the lithogenic effect of infusion of medium chain triglycerides being more pronounced than that of long chain triglycerides. This effect, coupled with gall bladder stasis, may be responsible for the increased risk of biliary sludge and gallstone formation in patients on long term lipid infusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:44:49