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Titolo:
Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment
Autore:
Rodrigues, CMP; Marin, JJG; Brites, D;
Indirizzi:
Univ Lisbon, Fac Farm, Ctr Patogenese Mol, P-1600 Lisbon, Portugal Univ Lisbon Lisbon Portugal P-1600 togenese Mol, P-1600 Lisbon, Portugal Inst Super Ciencias Saude Sul, Monte De Caparica, Portugal Inst Super Ciencias Saude Sul Monte De Caparica Portugal rica, Portugal Univ Salamanca, Dept Physiol & Pharmacol, E-37008 Salamanca, Spain Univ Salamanca Salamanca Spain E-37008 armacol, E-37008 Salamanca, Spain
Titolo Testata:
GUT
fascicolo: 3, volume: 45, anno: 1999,
pagine: 446 - 452
SICI:
0017-5749(199909)45:3<446:BAPIMA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRA-HEPATIC CHOLESTASIS; CHROMATOGRAPHY MASS SPECTROMETRY; INTRAHEPATIC CHOLESTASIS; PROGESTERONE METABOLITES; LIQUID-CHROMATOGRAPHY; DEVELOPMENTAL PATTERN; SERUM; THERAPY; URINE; MANAGEMENT;
Keywords:
bile acids; cholestasis; pregnancy; cholic acid; meconium; ursodeoxycholic acid therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Brites, D Univ Lisbon, Fac Farm, Ctr Patogenese Mol, Av Forcas Armadas, P-1600 Lisbon, Portugal Univ Lisbon Av Forcas Armadas Lisbon Portugal P-1600, Portugal
Citazione:
C.M.P. Rodrigues et al., "Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment", GUT, 45(3), 1999, pp. 446-452

Abstract

Background-Data on meconium bile acid composition in newborn babies of patients with intrahepatic cholestasis of pregnancy (ICP) are relatively scant, and changes that occur on ursodeoxycholic acid (UDCA) administration havenot been evaluated. Aims-To investigate bile acid profiles in meconium of neonates from untreated and UDCA treated patients with ICP. Maternal serum bile acid composition was also analysed both at diagnosis and delivery to determine whether this influences the concentration and proportion of bile acids in the meconium. Patients/Methods-The population included eight healthy pregnant women and 16 patients with ICP, nine of which received UDCA (12.5-15.0 mg/kg body weight/day) for 15+/-4 days until parturition. Bile acids were assessed in themeconium by gas chromatography-mass spectrometry and in maternal serum by high performance liquid chromatography. Results-Total bile acid and cholic acid concentrations in the increased (p<0.01) in newborns from patients with ICP (13.5 (5.1) and 8.4 (4.1) mu mol/g respectively; mean (SEM)) as compared with controls (2.0 (0.5) and 0.8 (0.3) mu mol/g respectively), reflecting the total bile acid and cholic acid levels in the maternal serum (r = 0.85 and r = 0.84, p<0.01). After UDCA administration, total bile acid concentrations decreased in the mother (similar to 3-fold, p<0.05) but not in the meconium. UDCA concentration in the meconium showed only a 2-fold increase after treatment, despite the much greater increase in the maternal serum (p<0.01). Lithocholic acid concentrationin the meconium was not increased by UDCA treatment. Conclusions-UDCA administration does not influence the concentration and proportion of bile acids in the meconium, which in turn are altered by ICP. Moreover, this beneficial treatment for the mother does not increase meconium levels of potentially toxic metabolites of UDCA such as lithocholic acid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:16:36