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Titolo:
Novel triazolo[4,3-a]quinazolinone and bis-triazolo[4,3-a : 4,3 '-c]quinazolines: synthesis and antitoxoplasmosis effect
Autore:
El-Tombary, AA; Ismail, KA; Aboulwafa, OM; Omar, AMME; El-Azzouni, MZ; El-Mansoury, ST;
Indirizzi:
Univ Alexandria, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21215, Egypt Univ Alexandria Alexandria Egypt 21215 eut Chem, Alexandria 21215, Egypt Univ Alexandria, Fac Med, Dept Parasitol, Alexandria 21215, Egypt Univ Alexandria Alexandria Egypt 21215 arasitol, Alexandria 21215, Egypt
Titolo Testata:
FARMACO
fascicolo: 7, volume: 54, anno: 1999,
pagine: 486 - 495
SICI:
0014-827X(19990730)54:7<486:NTAB:4>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOXOPLASMA-GONDII; PYRIMETHAMINE; MICE;
Keywords:
quinazoline; thiosemicarbazide; S-methylisothiosemicarbazide; cyclodesulfurization; triazolo and bis-triazoloquinazoline; antitoxoplasmosis effect;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Aboulwafa, OM Univ Alexandria, Fac Pharm, Dept Pharmaceut Chem, Alexandria21215, Egypt Univ Alexandria Alexandria Egypt 21215 andria 21215, Egypt
Citazione:
A.A. El-Tombary et al., "Novel triazolo[4,3-a]quinazolinone and bis-triazolo[4,3-a : 4,3 '-c]quinazolines: synthesis and antitoxoplasmosis effect", FARMACO, 54(7), 1999, pp. 486-495

Abstract

Several quinazoline derivatives containing substituted thiosemicarbazido and S-methylisothiosemicarbazido groups at the 2-position and at both the 2-and 4-positions have been synthesized. Treatment of the S-methylthiosemicarbazides with morpholine or diethylamine did not give the corresponding guanidines. Instead, they underwent cyclodesulfurization into the condensed ring systems, [1,2,4]triazolo[4,3-a]quinazolinones and bis-[1,2,4]triazolo[4,3-a :4',3'-c]quinazolines. Evaluation of the products for antitoxoplasmosiseffect by studying the ultrastructure morphology of the organisms using scanning electron microscopy (SEM) indicated their efficacy in causing structural deformity of Toxoplasma gondii. Such a deformity plays an important role in obstructing the entry of the organisms into host cells. (C) 1999 Elsevier Science S.A. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:02:02