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Titolo:
Nestin is expressed during development and in myotendinous and neuromuscular junctions in wild type and desmin knock-out mice
Autore:
Carlsson, L; Li, Z; Paulin, D; Thornell, LE;
Indirizzi:
Umea Univ, Dept Integrat Med Biol, Sect Anat, SE-90187 Umea, Sweden Umea Univ Umea Sweden SE-90187 ed Biol, Sect Anat, SE-90187 Umea, Sweden Umea Univ, Dept Musculoskeletal Res, SE-90187 Umea, Sweden Umea Univ Umea Sweden SE-90187 usculoskeletal Res, SE-90187 Umea, Sweden Univ Paris 07, F-75005 Paris, France Univ Paris 07 Paris France F-75005Univ Paris 07, F-75005 Paris, France
Titolo Testata:
EXPERIMENTAL CELL RESEARCH
fascicolo: 1, volume: 251, anno: 1999,
pagine: 213 - 223
SICI:
0014-4827(19990825)251:1<213:NIEDDA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERMEDIATE FILAMENT NESTIN; SKELETAL-MUSCLE; NERVOUS-SYSTEM; FIBERS; IDENTIFICATION; MEMBRANE; PROTEIN; CELLS; CARDIOMYOPATHY; LOCALIZATION;
Keywords:
desmin knock-out mice; cytoskeleton; intermediate filaments; immunocytochemistry; immunoelectron microscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Thornell, LE Umea Univ, Dept Integrat Med Biol, Sect Anat, SE-90187 Umea, Sweden Umea Univ Umea Sweden SE-90187 Anat, SE-90187 Umea, Sweden
Citazione:
L. Carlsson et al., "Nestin is expressed during development and in myotendinous and neuromuscular junctions in wild type and desmin knock-out mice", EXP CELL RE, 251(1), 1999, pp. 213-223

Abstract

Desmin, the main component of intermediate filaments (IFs) in mature skeletal muscle, forms an interlinking scaffold around myofibrils with connections to the sarcolemma and the nuclear membrane. Desmin is enriched in neuromuscular and myotendinous junctions. Mice lacking the desmin gene develop normally and reproduce. However, postnatally they develop a cardiomyopathy and a dystrophy in highly used muscles. We have investigated whether and how neuromuscular and myotendinous junctions are affected and whether nestin compensates for the lack of desmin in the knock-out (K/O) mice. We show that neither neuromuscular nor myotendinous junctions were markedly affected in the desmin K/O mice. In neuromuscular junctions nestin was present between the postjunctional folds and the subneural nuclei and between the nucleus and the myofibrillar cytoskeleton. In myotendinous junctions nestin was present between myofibrils at the Z-disc level and in longitudinal strands close to and at the junction. Nestin expression at these specialized sites, as well as during myogenesis and myofibrillogenesis, is independent of the presence of desmin. In desmin K/O mice nestin was also found in regenerating myofibers. The presence of nestin at neuromuscular and myotendinous junctions might provide enough strength for preservation and organization of the junctional areas, although desmin is lacking, (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 16:52:48