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Titolo:
Stimulation of haematogenous liver metastases by ischaemia-reperfusion in rats
Autore:
Ku, YS; Kusunoki, N; Shiotani, M; Maeda, I; Iwasaki, T; Tominaga, M; Kitagawa, T; Fukumoto, T; Suzuki, Y; Kuroda, Y;
Indirizzi:
Kobe Univ, Sch Med, Dept Surg 1, Chuo Ku, Kobe, Hyogo 650, Japan Kobe Univ Kobe Hyogo Japan 650 pt Surg 1, Chuo Ku, Kobe, Hyogo 650, Japan
Titolo Testata:
EUROPEAN JOURNAL OF SURGERY
fascicolo: 8, volume: 165, anno: 1999,
pagine: 801 - 807
SICI:
1102-4151(199908)165:8<801:SOHLMB>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA-REPERFUSION; HEPATIC METASTASES; HYALURONIC-ACID; KILLER CELLS; INJURY; TRANSPLANTATION; GROWTH; METABOLISM; ASCITES; MODEL;
Keywords:
hepatic ischemia; hematogenous metastasis; liver tumours; rat ascitic hepatoma; hyaluronic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Ku, YS Kobe Univ, Sch Med, Dept Surg 1, Chuo Ku, Kusunoki Cho, Kobe, Hyogo650, Japan Kobe Univ Kusunoki Cho Kobe Hyogo Japan 650 Kobe, Hyogo 650, Japan
Citazione:
Y.S. Ku et al., "Stimulation of haematogenous liver metastases by ischaemia-reperfusion in rats", EURO J SURG, 165(8), 1999, pp. 801-807

Abstract

Objective: To find out whether hepatic ischaemia-reperfusion stimulates hepatic tumour metastases using a cell line of rat ascitic hepatoma (AH130). Design: Prospective experimental study. Setting: University laboratories, Japan. Materials: 118 male Donryu rats. Intervention: After laparotomy alone (group 1, n=35) or laparotomy and 20-minutes ischaemia (group 2, n=34) or laparotomy and 30-minutes ischaemia (group 3, n=34) of the median and left hepatic lobes, the animals were given either an intraportal injection of 1 x 10(5) or an intravenous injection of1 x 10(6) viable AH130 cells. Main outcome measures: 10 days after inoculation of tumour cells the number of nodules on the surface of the right lobe and of the median plus left lobes were separately counted for each Liver. Results: Irrespective of the route of tumour inoculation in group 1, therewas no significant difference in the number of tumours/ g liver between the right and the median plus left lobes. However, in groups 2 and 3, the number of tumours/g liver in the median plus left lobes was significantly higher than in the right lobe (p < 0.05). Furthermore, in the median plus left lobes, animals who had had 30 minutes of ischaemia had significantly more tumours than those in the other two groups (p < 0.01). Conclusion: Hepatic ischaemia-reperfusion may increase the risk of development of haematogenous liver metastases, by stimulating tumour cell-endothelial cell interactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 21:01:29