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Titolo:
Concentrations of free steroids in the jugular and hepatic portal veins ofpigs after ingestion of testosterone, estrogen, or progesterone or transplantation of ovaries to the intestine
Autore:
Dziuk, PJ; Parvizi, N; Ellendorff, F;
Indirizzi:
Inst Tierzucht & Tierverhalten, D-31535 Neustadt, Germany Inst Tierzucht &Tierverhalten Neustadt Germany D-31535 eustadt, Germany
Titolo Testata:
DOMESTIC ANIMAL ENDOCRINOLOGY
fascicolo: 1, volume: 17, anno: 1999,
pagine: 29 - 38
SICI:
0739-7240(199907)17:1<29:COFSIT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ABSORPTION; METABOLISM; DUODENUM; CYCLE;
Keywords:
steroids; metabolism; ovarian transplantation; enterohepatic recycling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Dziuk, PJ Univ Illinois, Dept Anim Sci, 1207 W Gregory Dr, Urbana, IL 61801 USA Univ Illinois 1207 W Gregory Dr Urbana IL USA 61801 IL 61801 USA
Citazione:
P.J. Dziuk et al., "Concentrations of free steroids in the jugular and hepatic portal veins ofpigs after ingestion of testosterone, estrogen, or progesterone or transplantation of ovaries to the intestine", DOM ANIM EN, 17(1), 1999, pp. 29-38

Abstract

Estrogen, progesterone or testosterone were administered orally to ovariectomized gilts fitted with indwelling catheters. Blood samples were taken from the jugular and hepatic portal veins at intervals varying from a few minutes to daily over periods that varied from 1 d to several months. Concentrations of free steroids rose dramatically in the hepatic portal vein withina few min of feeding steroids and remained high for 3-8 hr before declining to base levels. Concentrations in the jugular vein sometimes rose very slightly for the same period. At 48 hr after administration the concentrations remained at baseline in the hepatic portal vein, but rose several-fold inthe jugular and remained elevated for several days. Autotransplantation ofthe ovaries to the intestine resulted in very large ovaries consisting of many large, heavily luteinized cystic follicles. Concentrations of progesterone and estrogen in the hepatic portal vein were very high, but were low in the jugular vein. The gut wall allows for passage of some orally administered free steroids to the liver via the hepatic portal vein. The free steroids are essentially metabolized before they reach the jugular vein, but canbe recirculated via the enterohepatic route. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:36:15