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Titolo:
Potential future therapies: natriuretic peptides
Autore:
Lisy, O; Burnett, JC;
Indirizzi:
Mayo Clin & Mayo Fdn, Dept Physiol, Div Cardiovasc Dis, Cardiorenal Res Lab, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Lab, Rochester, MN 55905 USA
Titolo Testata:
CORONARY ARTERY DISEASE
fascicolo: 6, volume: 10, anno: 1999,
pagine: 389 - 394
SICI:
0954-6928(199909)10:6<389:PFTNP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; LEFT-VENTRICULAR DYSFUNCTION; NEUTRAL ENDOPEPTIDASE INHIBITION; CARDIOVASCULAR-DISEASE; INTRAVENOUS-INJECTION; PLASMA-LEVELS; ATRIAL; INFUSION; RATS; DOGS;
Keywords:
natriuretic peptides; congestive heart failure; neutral endopeptidase; early asymptomatic left ventricular dysfunction;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Lisy, O Mayo Clin & Mayo Fdn, Dept Physiol, Div Cardiovasc Dis, Cardiorenal Res Lab, Guggenheim 915,200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Guggenheim 915,200 1st St SW Rochester MN USA 55905
Citazione:
O. Lisy e J.C. Burnett, "Potential future therapies: natriuretic peptides", CORON ART D, 10(6), 1999, pp. 389-394

Abstract

Congestive heart failure has become a major public health problem. A hallmark of this syndrome is neurohumoral activation, with elevation of natriuretic peptides, in particular atrial natriuretic peptide and brain natriuretic peptide of myocardial origin, which occurs with the onset of ventricular dysfunction. The natriuretic peptide system is important in cardiorenal regulation, specifically in the integrated control of intravascular volume andarterial pressure to maintain optimal circulatory integrity Several therapeutic approaches have been established to mimic or potentiate the unique cardiovascular and renal beneficial actions of these peptides during heart failure. Recent investigations have also established a diagnostic utility forthe natriuretic peptides to diagnose early asymptomatic left ventricular dysfunction. Thus, diagnostic and therapeutic use of the natriuretic peptides is emerging as a new strategy to delay the natural history of progressiveheart failure from its earliest phase to chronic congestive heart failure. Coronary Artery Dis 10:389-394 (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:32:20