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Titolo:
Estrogen replacement therapy, serum lipids, and polymorphism of the apolipoprotein E gene
Autore:
Garry, PJ; Baumgartner, RN; Brodie, SG; Montoya, GD; Liang, HC; Lindeman, RD; Williams, TM;
Indirizzi:
Univ New Mexico, Hlth Sci Ctr, Dept Pathol, Albuquerque, NM 87131 USA UnivNew Mexico Albuquerque NM USA 87131 athol, Albuquerque, NM 87131 USA Univ New Mexico, Hlth Sci Ctr, Dept Med, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 t Med, Albuquerque, NM 87131 USA Univ New Mexico, Hlth Sci Ctr, Clin Nutr Program, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 ogram, Albuquerque, NM 87131 USA NIDDKD, Genet Dev & Dis Branch, NIH, Bethesda, MD 20892 USA NIDDKD Bethesda MD USA 20892 ev & Dis Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
CLINICAL CHEMISTRY
fascicolo: 8, volume: 45, anno: 1999,
parte:, 1
pagine: 1214 - 1223
SICI:
0009-9147(199908)45:8<1214:ERTSLA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL; HEALTHY ELDERLY POPULATION; POSTMENOPAUSAL WOMEN; PLASMA-LIPOPROTEINS; ARTERY DISEASE; METABOLISM; LIPASE; ATHEROSCLEROSIS; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Garry, PJ Univ New Mexico, Hlth Sci Ctr, Dept Pathol, Room 215,Surge Bldg,2701 Frontier Pl NE, Albuquerque, NM 87131 USA Univ New Mexico Room 215,Surge Bldg,2701 Frontier Pl NE Albuquerque NM USA 87131
Citazione:
P.J. Garry et al., "Estrogen replacement therapy, serum lipids, and polymorphism of the apolipoprotein E gene", CLIN CHEM, 45(8), 1999, pp. 1214-1223

Abstract

Background: Pharmacogenomics, the study of genetic loci that modulate drugresponsiveness, may help to explain why estrogen replacement therapy (ERT)has differential effects on serum lipid and lipoprotein concentrations hn postmenopausal women who inherit distinct alleles of the apolipoprotein E gene (APOE). Methods: We compared total-cholesterol, triglyceride, and lipoprotein (LDLand HDL) concentrations in 66 postmenopausal women receiving ERT ([+]ERT) with 174 postmenopausal women not receiving ERT ([-]ERT), controlling for three APOE genotypes divided into three groups: E2 (epsilon 2/epsilon 3, n =31), E3 (epsilon 3/epsilon 3, n = 160), and E4 (epsilon 3/epsilon 4 + epsilon 4/epsilon 4, n = 49). Results: Mean total-cholesterol concentrations were lower in all three [+]ERT groups compared with their [-]ERT counterparts but were statistically significant only for women in group E4 (P = 0.014). The mean LDL-cholesterolconcentrations were significantly lower in all three [+]ERT groups compared with their [-]ERT counterparts (P less than or equal to 0.005). Although all three groups of [+]ERT women fended to have higher mean HDL-cholesterolconcentrations compared with their [-]ERT counterparts, the differences were not statistically significant. [+]ERT women in groups E2 and E3 had significantly higher (P <0.05) triglyceride concentrations than their [-]ERT counterparts, In [+]ERT women, the ratios of total and LDL-cholesterol to HDL-cholesterol were significantly higher in group E3 and E4 women compared with E2 women (P<0.006). Group E4 [+]ERT women had ratios of total and LDL-cholesterol to HDL-cholesterol that were comparable to group E2 [-]ERT women. Conclusions: Triglyceride concentrations in group E2 [+]ERT women may needto be monitored more closely than those in E3 or E4 [+]ERT women. Group E4women should probably be targeted for ERT. Results suggest that APOE genotypes have a differential effect on serum lipids and lipoproteins in [+]ERT postmenopausal women. (C) 1999 American Association for Clinical Chemistry.

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Documento generato il 19/09/20 alle ore 08:11:40