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Titolo:
Androgen imbalance in premenopausal women with benign breast disease and breast cancer
Autore:
Lee, SH; Kim, SO; Kwon, SW; Chung, BC;
Indirizzi:
Korea Adv Inst Sci & Technol, Bioanal & Biotransformat Res Ctr, Seoul 130650, South Korea Korea Adv Inst Sci & Technol Seoul South Korea 130650 30650, South Korea Sungshin Womens Univ, Dept Chem, SungBuk Gu, Seoul 136742, South Korea Sungshin Womens Univ Seoul South Korea 136742 Seoul 136742, South Korea Yonsei Univ, Coll Med, Dept Gen Surg, Kangnam Gu, Seoul 135270, South Korea Yonsei Univ Seoul South Korea 135270 ngnam Gu, Seoul 135270, South Korea
Titolo Testata:
CLINICAL BIOCHEMISTRY
fascicolo: 5, volume: 32, anno: 1999,
pagine: 375 - 380
SICI:
0009-9120(199907)32:5<375:AIIPWW>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
RISK; HORMONES; RECEPTOR; LESIONS;
Keywords:
breast cancer; benign breast disease; androgens; corticoids; gas chromatography-mass spectrometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, SH Korea Adv Inst Sci & Technol, Bioanal & Biotransformat Res Ctr, POB 131, Seoul 130650, South Korea Korea Adv Inst Sci & Technol POB 131 Seoul South Korea 130650 rea
Citazione:
S.H. Lee et al., "Androgen imbalance in premenopausal women with benign breast disease and breast cancer", CLIN BIOCH, 32(5), 1999, pp. 375-380

Abstract

Objective: The alteration of steroid hormonal status in premenopausal breast disease (benign and malignant) were investigated by comparing the urinary profile of androgens and corticoids. Methods: The urinary concentrations of 25 androgens and corticoids were quantitatively determined by a gas chromatography-mass spectrometry system inpatients with benign breast disease (35 cases, 20-54 years), breast cancer(34, 27-54), and healthy controls of similar age (25, 22-51). Results: In premenopausal patients with breast cancer, a significantly lower rate of excretion of 11-deoxy-17-ketosteroids and their metabolites was found in comparison with normal females. These levels were also inversely associated with benign breast disease. No significant differences were foundbetween the three groups for the concentration of 11-oxy-17-ketosteroids, 17-hydroxy-corticoids and their metabolites. The urinary ratio of adrenal androgen metabolites to cortisol metabolites [(11-DOKS & M)/11-OKS] declinedin the order of normal female control (4.04 +/- 0.72; mean +/- SD), breastbenign mass (2.29 +/- 0.42) and breast cancer (0.94 +/- 0.27). Conclusion: Our data suggest that the hormonal imbalance of androgen deficiency and/or corticoid sufficiency is closely associated with the benign and malignant conditions of premenopausal breast disease and the ratio of (11-DOKS & M)/11-OKS may be an effective discriminant factor of these groups. Copyright (C) 1999 The Canadian Society of Clinical Chemists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 09:36:18