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Titolo:
Correlation between the administered dose of DHEA and serum levels of DHEAand DHEA-S in human volunteers: Analysis of published data
Autore:
Tummala, S; Svec, F;
Indirizzi:
Louisiana State Univ, Sch Med, Obes Res Program, Sect Endocrinol,Dept Med,New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 d,New Orleans, LA 70112 USA
Titolo Testata:
CLINICAL BIOCHEMISTRY
fascicolo: 5, volume: 32, anno: 1999,
pagine: 355 - 361
SICI:
0009-9120(199907)32:5<355:CBTADO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEHYDROEPIANDROSTERONE-SULFATE; ORAL DEHYDROEPIANDROSTERONE; POSTMENOPAUSAL WOMEN; INFLUENZA VACCINATION; INSULIN-RESISTANCE; IMMUNE FUNCTION; MEN; REPLACEMENT; NEUROSTEROIDS; METABOLISM;
Keywords:
dehydroepiandrosterone; aging; adrenal hormones; serum analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Svec, F Louisiana State Univ, Med Ctr, Endocrinol Sect, 1542 Tulane Ave, New Orleans, LA 70112 USA Louisiana State Univ 1542 Tulane Ave New Orleans LA USA 70112 USA
Citazione:
S. Tummala e F. Svec, "Correlation between the administered dose of DHEA and serum levels of DHEAand DHEA-S in human volunteers: Analysis of published data", CLIN BIOCH, 32(5), 1999, pp. 355-361

Abstract

Objectives: Studies from both experimental animals and humans suggest thatadministration of exogenous DHEA may have beneficial endocrine-metabolic, immunologic and neurologic effects. Several groups have administered DHEA to humans, but to the best of our knowledge, no one at this point has published a summary of the relationship between the administered dose of DHEA andthe serum levels of steroids attained. Design: We summarize the relationship between the administered dose of DHEA and the resulting serum level of DHEA and DHEA-S, in humans, from 18 published articles. Results: Serum levels of DHEA and DHEA-S increase with increasing doses. Doses above 50 mg/day result in levels that are at or above the upper limit of normal for healthy young adults. At doses above 300 mg/day the incrementof serum DHEA and DHEA-S appears to reach a plateau. Conclusions: Those wanting to use supplemental DHEA might consider that doses of 300 mg/day are maximal; they clearly result in supraphysiologic concentrations and above this level doses may have increased side effects without significantly increasing the effective level of serum hormone. Copyright(C) 1999 The Canadian Society of Clinical Chemists.

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Documento generato il 28/11/20 alle ore 00:40:20