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Titolo:
Tumour necrosis factor-alpha induces Langerhans cell migration in humans
Autore:
Cumberbatch, M; Griffiths, CEM; Tucker, SC; Dearman, RJ; Kimber, I;
Indirizzi:
Zeneca Cent Toxicol Lab, Macclesfield SK10 4TJ, Cheshire, England Zeneca Cent Toxicol Lab Macclesfield Cheshire England SK10 4TJ e, England Univ Manchester, Hope Hosp, Dermatol Ctr, Salford M6 8HD, Lancs, England Univ Manchester Salford Lancs England M6 8HD lford M6 8HD, Lancs, England
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 2, volume: 141, anno: 1999,
pagine: 192 - 200
SICI:
0007-0963(199908)141:2<192:TNFILC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRAINING LYMPH-NODES; ADHESION MOLECULE EXPRESSION; DENDRITIC CELLS; E-CADHERIN; CONTACT SENSITIZATION; FLUORESCEIN ISOTHIOCYANATE; IN-VIVO; ANTIGEN; INTERLEUKIN-1-BETA; RECEPTOR;
Keywords:
CD1a; HLA-DR; human; immune response; Langerhans cells; migration; tumour necrosis factor-alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Cumberbatch, M Zeneca Cent Toxicol Lab, Alderley Pk, Macclesfield SK10 4TJ, Cheshire, England Zeneca Cent Toxicol Lab Alderley Pk Macclesfield Cheshire England SK10 4TJ
Citazione:
M. Cumberbatch et al., "Tumour necrosis factor-alpha induces Langerhans cell migration in humans", BR J DERM, 141(2), 1999, pp. 192-200

Abstract

The role of tumour necrosis factor (TNF)-alpha in the mobilization and migration of human epidermal Langerhans cells (LC) has been investigated. Intradermal injection of normal human volunteers with homologous recombinant TNF-alpha. was found to cause a dose-dependent reduction in the frequency of LC within epidermal sheets 2h later. Equivalent results were obtained when epidermal LC were identified on the basis of either CD1a or HLA-DR expression. At the dose of TNF-alpha used routinely (500 U), treatment resulted in an average reduction in LC density of approximately 24%. Treatment with TNF-alpha was associated with a perivascular polymorphonuclear infiltration at2 h, but the epidermis appeared normal with neither fibrinoid necrosis norvasculitis, and LC morphology was not affected significantly. These results demonstrate that TNF-alpha provides an important signal for LC migration in humans and is likely therefore to play a crucial part in the induction of cutaneous immune responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 03:15:15