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Titolo:
Diabetes mellitus, other medical conditions and familial history of canceras risk factors for pancreatic cancer
Autore:
Silverman, DT; Schiffman, M; Everhart, J; Goldstein, A; Lillemoe, KD; Swanson, GM; Schwartz, AG; Brown, LM; Greenberg, RS; Schoenberg, JB; Pottern, LM; Hoover, RN; Fraumeni, JF;
Indirizzi:
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Canc Epidemiol & Genet, Bethesda, MD 20892 USA NIDDKD, Div Digest Dis & Nutr, Bethesda, MD 20892 USA NIDDKD Bethesda MD USA 20892 iv Digest Dis & Nutr, Bethesda, MD 20892 USA Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 t Surg, Baltimore, MD 21205 USA Michigan Canc Fdn, Detroit, MI 48201 USA Michigan Canc Fdn Detroit MI USA48201 an Canc Fdn, Detroit, MI 48201 USA Emory Univ, Sch Publ Hlth, Div Epidemiol, Atlanta, GA USA Emory Univ Atlanta GA USA Sch Publ Hlth, Div Epidemiol, Atlanta, GA USA New Jersey State Dept Hlth, Special Epidemiol Program, Trenton, NJ 08625 USA New Jersey State Dept Hlth Trenton NJ USA 08625 am, Trenton, NJ 08625 USA NIH, Off Director, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892NIH, Off Director, Bethesda, MD 20892 USA
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 11, volume: 80, anno: 1999,
pagine: 1830 - 1837
SICI:
0007-0920(199908)80:11<1830:DMOMCA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POPULATION-BASED COHORT; PARTIAL GASTRECTOMY; COLORECTAL-CANCER; DIRECT INTERVIEWS; GASTRIC-SURGERY; UNITED-STATES; HAMSTER MODEL; PEPTIC-ULCER; CARCINOMA; ALCOHOL;
Keywords:
diabetes mellitus; cholecystectomy; allergies; family history of cancer; pancreatic neoplasm;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Silverman, DT NCI, Div Canc Epidemiol & Genet, Execut Plaza S,Room 8108, Bethesda, MD 20892 USA NCI Execut Plaza S,Room 8108 Bethesda MD USA 20892 20892 USA
Citazione:
D.T. Silverman et al., "Diabetes mellitus, other medical conditions and familial history of canceras risk factors for pancreatic cancer", BR J CANC, 80(11), 1999, pp. 1830-1837

Abstract

In a population-based case-control study of pancreatic cancer conducted inthree areas of the USA, 484 cases and 2099 controls were interviewed to evaluate the aetiologic role of several medical conditions/interventions, including diabetes mellitus, cholecystectomy, ulcer/gastrectomy and allergic states. We also evaluated risk associated with family history of cancer. Ourfindings support previous studies indicating that diabetes is a risk factor for pancreatic cancer, as well as a possible complication of the tumour. A significant positive trend in risk with increasing years prior to diagnosis of pancreatic cancer was apparent (P-value for test of trend = 0.016), with diabetics diagnosed at least 10 years prior to diagnosis having a significant 50% increased risk. Those treated with insulin had risks similar to those not treated with insulin (odds ratio (OR) = 1.6 and 1.5 respectively), and no trend in risk was associated with increasing duration of insulin treatment. Cholecystectomy also appeared to be a risk factor, as well as a consequence of the malignancy. Subjects with a cholecystectomy at least 20 years prior to the diagnosis of pancreatic cancer experienced a 70% increased risk, which was marginally significant. In contrast, subjects with a history of duodenal or gastric ulcer had little or no elevated risk (OR = 1.2, confidence interval = 0.9-1.6). Those treated by gastrectomy had the same risk as those not receiving surgery, providing little support for the hypothesis that gastrectomy is a risk factor for pancreatic cancer. A significant40% reduced risk was associated with hay fever, a non-significant 50% decreased risk with allergies to animals, and a non-significant 40% reduced risk with allergies to dust/moulds. These associations; however, may be due tochance since no risk reductions were apparent for asthma or several other types of allergies. In addition, we observed significantly increased risks for subjects reporting a first-degree relative with cancers of the pancreas(OR = 3.2), colon (OR = 1.7) or ovary (OR = 5.3) and non-significantly increased risks for cancers of the endometrium (OR = 1.5) or breast (OR = 1.3). The pattern is consistent with the familial predisposition reported for pancreatic cancer and with the array of tumours associated with hereditary non-polyposis colon cancer.

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Documento generato il 05/07/20 alle ore 06:35:51