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Titolo:
Effects of i.v. anaesthetic agents on the chemotaxis of eosinophils in vitro
Autore:
Krumholz, W; Abdulle, O; Knecht, J; Hempelmann, G;
Indirizzi:
Bethlehem Krankenhaus, Abt Anaesthesie & Operat Intens Med, D-52222 Stolberg, Germany Bethlehem Krankenhaus Stolberg Germany D-52222 D-52222 Stolberg, Germany Univ Giessen, Anaesthesiol & Operat Intens Med Abt, D-35385 Giessen, Germany Univ Giessen Giessen Germany D-35385 s Med Abt, D-35385 Giessen, Germany
Titolo Testata:
BRITISH JOURNAL OF ANAESTHESIA
fascicolo: 2, volume: 83, anno: 1999,
pagine: 333 - 335
SICI:
0007-0912(199908)83:2<333:EOIAAO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAPID METHOD; GRANULOCYTES;
Keywords:
blood, eosinophils; anaesthetics i.v., thiopental; anaesthetics i.v., methohexital; anaesthetics i.v., propofol; anaesthetics i.v., etomidate; anaesthetics i.v., ketamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Krumholz, W Bethlehem Krankenhaus, Abt Anaesthesie & Operat Intens Med, Steinfeldstr 5, D-52222 Stolberg, Germany Bethlehem Krankenhaus Steinfeldstr 5 Stolberg Germany D-52222
Citazione:
W. Krumholz et al., "Effects of i.v. anaesthetic agents on the chemotaxis of eosinophils in vitro", BR J ANAEST, 83(2), 1999, pp. 333-335

Abstract

Polymorphonuclear eosinophilic leucocytes (PME) participate in wound healing processes, the inflammatory response, bronchial asthma, allergies and defence against invading parasites. We have examined the effects of thiopental, methohexital, propofol, etomidate and ketamine on PME chemotaxis in vitro. PME were isolated from venous blood samples of 10 healthy volunteers using multi-stage Percoll gradient centrifugation. Eosinophilic chemotaxis wasdetermined using a 48-well microchemotaxis chamber. Thiopental 150 mu g ml(-1) and etomidate 0.32 mu g ml(-1) caused significant (P less than or equal to 0.05) inhibition of PME chemotaxis. We conclude that thiopental and etomidate may have an adverse influence on wound healing processes and parasitic diseases. Further studies are recommended.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 11:11:25