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Titolo:
Morphological correlates of the differential responses of muscles to vecuronium
Autore:
Ibebunjo, C; Srikant, CB; Donati, F;
Indirizzi:
Royal Victoria Hosp, Dept Anaesthesia, Montreal, PQ H3A 1A1, Canada Royal Victoria Hosp Montreal PQ Canada H3A 1A1 ntreal, PQ H3A 1A1, Canada Royal Victoria Hosp, Dept Med, Montreal, PQ H3A 1A1, Canada Royal VictoriaHosp Montreal PQ Canada H3A 1A1 ntreal, PQ H3A 1A1, Canada McGill Univ, Montreal, PQ H3A 1A1, Canada McGill Univ Montreal PQ Canada H3A 1A1 Univ, Montreal, PQ H3A 1A1, Canada
Titolo Testata:
BRITISH JOURNAL OF ANAESTHESIA
fascicolo: 2, volume: 83, anno: 1999,
pagine: 284 - 291
SICI:
0007-0912(199908)83:2<284:MCOTDR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADDUCTOR POLLICIS MUSCLES; NEUROMUSCULAR BLOCKING-AGENTS; ACETYLCHOLINE-RECEPTORS; LIMB MUSCLES; BLOOD-FLOW; DIAPHRAGM; BLOCKADE; MASSETER; GOAT; SUCCINYLCHOLINE;
Keywords:
neuromuscular block, vecuronium; muscle skeletal; muscle skeletal, responses; cat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ibebunjo, C Shriners Hosp Crippled Children, 51 Blossom St,2nd Floor, Boston, MA 02114USA Shriners Hosp Crippled Children 51 Blossom St,2nd Floor Boston MA USA 02114
Citazione:
C. Ibebunjo et al., "Morphological correlates of the differential responses of muscles to vecuronium", BR J ANAEST, 83(2), 1999, pp. 284-291

Abstract

We have noted previously that duration of vecuronium block correlated withfibre size in six muscle groups in the goat. Electrophysiological considerations suggest that the important factor should be the number of acetylcholine receptors (AChR) relative to fibre size. However, this hypothesis couldnot be verified in the goat because the number of AChR was relatively constant in the different muscles despite differences in fibre size. Therefore,in this study, we have investigated the relationship between sensitivity to vecuronium, as reflected by the ED50 and duration of block, of six muscles in the cat and the number of AChR per unit fibre cross-sectional area (CSA). The ED50 and duration of action (time to 50% recovery of the first twitch after a dose of 15 mu g kg(-1)) of vecuronium in the tibialis cranialis,soleus, rectus abdominis, masseter, diaphragm and thyroarytenoideus muscles were determined during train-of-four stimulation and EMG recording in seven cats anaesthetized with pentobarbital. CSA of the muscle fibres and number of junctional AChR in these muscles were measured by histological methods and I-125-alpha-bungdrotoxin binding assay, respectively, and the number of AChR per unit fibre CSA calculated. The association between muscle response (ED50 and duration of block) and fibre CSA or number of AChR per unit fibre CSA was then tested by regression analyses. Duration of block varied between the six muscles (mean 8.9 (SEM 2.6) to 20.3 (3.1) min; P = 0.0001) but ED50 did not (7.5 (1.5) to 15.6 (2.5) mu g kg(-1); P = 0.185). Fibre CSAand number of AChR per unit fibre CSA also varied between these muscles (P= 0.0001). Duration to 50% TI recovery was prolonged in muscles with a lownumber of AChR relative to fibre CSA (r(2) = 0.30; P = 0.0002) and the ED50 increased as the number of AChR per fibre CSA increased (r(2) = 0.240; P = 0.0016). These results in the cat suggest that the number of junctional AChR relative to fibre CSA is a morphological predictor of the differential sensitivities of muscles to neuromuscular blocking agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:10:47