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Titolo:
Effect of a glutamate receptor antagonist (GYKI 52466) on 4-aminopyridine-induced seizure activity developed in rat cortical slices
Autore:
Doczi, J; Banczerowski-Pelyhe, I; Barna, B; Vilagi, I;
Indirizzi:
Lorand Eotvos Univ, Dept Physiol & Neurobiol, Budapest, Hungary Lorand Eotvos Univ Budapest Hungary siol & Neurobiol, Budapest, Hungary Attila Jozsef Univ, Dept Comparat Physiol, Szeged, Hungary Attila Jozsef Univ Szeged Hungary ept Comparat Physiol, Szeged, Hungary
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 6, volume: 49, anno: 1999,
pagine: 435 - 440
SICI:
0361-9230(199908)49:6<435:EOAGRA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GABA-MEDIATED POTENTIALS; AMINO-ACID ANTAGONISTS; EPILEPTIFORM DISCHARGES; IN-VITRO; ANTICONVULSANT ACTIVITY; NEOCORTICAL NEURONS; HIPPOCAMPAL SLICES; FIELD POTENTIALS; GYKI-52466; NBQX;
Keywords:
epilepsy model; 4-aminopyridine; GYKI 52466; microelectrophysiology; brain slice study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Vilagi, I Lorand Eotvos Univ, Dept Physiol & Neurobiol, Muzeum Krt 4-A, Budapest, Hungary Lorand Eotvos Univ Muzeum Krt 4-A Budapest Hungary st, Hungary
Citazione:
J. Doczi et al., "Effect of a glutamate receptor antagonist (GYKI 52466) on 4-aminopyridine-induced seizure activity developed in rat cortical slices", BRAIN RES B, 49(6), 1999, pp. 435-440

Abstract

In the present experiments we have tested the effect of the noncompetitiveAMPA antagonist GYKI 52466 (20-80 mu M) on spontaneous epileptic discharges developed as the consequence of 4-aminopyridine application in neocortex slices of adult rats. Parallel to the changes of spontaneous activity, the field potentials, evoked by electrical stimulation of the corpus callosum, were also analyzed, Glass microcapillary extracellular recording electrode was positioned in the third layer of the somatosensory cortex slice, while the stimulating electrode was placed at the border of the white and gray matter. 4-aminopyridlne and GYKI 52466 were bath-applied. The application of 40 mu M GYKI 52466 caused about 40% decrease in the frequency and the amplitude of spontaneous seizures as well as the duration of each discharges developed in 4-aminopyridine, Pre-incubation with the AMPA antagonist effectively inhibited both the development of seizure activity and the maintenance of the discharges. GYKI 52466 also decreased the duration and amplitude of field responses evoked by stimulation of the corpus callosum. This inhibitory effect was dose-dependent, Our data in the in vitro cortex slice epilepsy model suggest that the non-competitive AMPA antagonist GYKI 52466 is a potent anticonvulsant and neuroprotective compound because it reduced the fully developed epileptic discharges or prevented their development. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:13:48