Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Specific cognitive deficits in mild frontal variant frontotemporal dementia
Autore:
Rahman, S; Sahakian, BJ; Hodges, JR; Rogers, RD; Robbins, TW;
Indirizzi:
Univ Cambridge, Dept Psychiat, Cambridge, England Univ Cambridge Cambridge England dge, Dept Psychiat, Cambridge, England Univ Cambridge, Dept Neurol, Cambridge, England Univ Cambridge CambridgeEngland ridge, Dept Neurol, Cambridge, England Univ Cambridge, MRC, Cognit & Brain Sci Unit, Cambridge, England Univ Cambridge Cambridge England t & Brain Sci Unit, Cambridge, England Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England Univ Cambridge, MRC, Ctr Brain Repair, Cambridge, England Univ Cambridge Cambridge England , Ctr Brain Repair, Cambridge, England
Titolo Testata:
BRAIN
, volume: 122, anno: 1999,
parte:, 8
pagine: 1469 - 1493
SICI:
0006-8950(199908)122:<1469:SCDIMF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-ALZHEIMER TYPE; SPATIAL WORKING-MEMORY; TEMPORAL-LOBE EXCISIONS; HUMAN PREFRONTAL CORTEX; CARD SORTING TEST; PARKINSONS-DISEASE; HUNTINGTONS-DISEASE; AMYGDALO-HIPPOCAMPECTOMY; TRYPTOPHAN DEPLETION; ORBITOFRONTAL CORTEX;
Keywords:
frontotemporal dementia; decision-making; reversal learning; orbitofrontal prefrontal cortex; ventromedial prefrontal cortex;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
118
Recensione:
Indirizzi per estratti:
Indirizzo: Sahakian, BJ Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Dept Psychiat, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ e CB2 2QQ, England
Citazione:
S. Rahman et al., "Specific cognitive deficits in mild frontal variant frontotemporal dementia", BRAIN, 122, 1999, pp. 1469-1493

Abstract

Eight patients with relatively mild frontal variant frontotemporal dementia (fvFTD) were compared with age- and IQ-matched control volunteers on tests of executive and mnemonic function. Tests of pattern and spatial recognition memory, spatial span, spatial working memory, planning, visual discrimination learning/attentional set-shifting and decision-making were employed. Patients with fvFTD were found to have deficits in the visual discrimination learning paradigm specific to the reversal stages. Furthermore, in the decision-making paradigm, patients were found to show genuine risk-taking behaviour with increased deliberation times rather than merely impulsive behaviour. It was especially notable that these patients demonstrated virtuallyno deficits in other tests that have also been shown to be sensitive to frontal lobe dysfunction, such as the spatial working memory and planning tasks. These results are discussed in relation to the possible underlying neuropathology, the anatomical connectivity and the hypothesized heterogeneous functions of areas of the prefrontal cortex. In particular, given the nature of the cognitive deficits demonstrated by these patients, we postulate that, relatively early in the course of the disease, the ventromedial (or orbitofrontal) cortex is a major locus of dysfunction and that this may relateto the behavioural presentation of these patients clinically described in the individual case histories.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:30:20