Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Neurochemical brain imaging investigations of schizophrenia
Autore:
Soares, JC; Innis, RB;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, Neurochem Brain Imaging Program, New Haven, CT USA Yale Univ New Haven CT USA chem Brain Imaging Program, New Haven, CT USA VA Connecticut Healthcare Syst, W Haven, CT USA VA Connecticut Healthcare Syst W Haven CT USA care Syst, W Haven, CT USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 5, volume: 46, anno: 1999,
pagine: 600 - 615
SICI:
0006-3223(19990901)46:5<600:NBIIOS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; POSITRON EMISSION TOMOGRAPHY; DOPAMINE D-2 RECEPTORS; LIVING HUMAN BRAIN; DRUG-NAIVE SCHIZOPHRENICS; PRIMATE CEREBRAL-CORTEX; PREFRONTAL CORTEX; IN-VIVO; I-125 EPIDEPRIDE; D2 RECEPTORS;
Keywords:
schizophrenia; neuroimaging; receptor imaging; PET; SPECT; MRS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
161
Recensione:
Indirizzi per estratti:
Indirizzo: Soares, JC Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, 3811 OHara St, Pittsburgh, PA 15213 USA Univ Pittsburgh 3811 OHara St Pittsburgh PA USA 15213 15213 USA
Citazione:
J.C. Soares e R.B. Innis, "Neurochemical brain imaging investigations of schizophrenia", BIOL PSYCHI, 46(5), 1999, pp. 600-615

Abstract

Neurochemical brain imaging methods developed over the past 20 years offersignificant promise for elucidating the biochemical underpinnings of schizophrenia. The two general methodologies used for these studies have been: 1) radiotracer imaging: PET (positron emission tomography) and SPECT (singlephoton emission computed tomography); and 2) NMR (nuclear magnetic resonance) imaging: fMRI (functional magnetic resonance imaging) and MRS (magneticresonance spectroscopy). Despite conflicting findings, striatal D-2 receptor density may be elevated in some, but not all patients. Elevated synthesis, and increased release of dopamine after amphetamine challenge have also been reported. Imaging of cortical 5-HT2A receptors suggests that this system is unaffected, in conflict with findings of postmortem studies. Althoughprior postmortem studies suggested an increase in cortical GABA(A) receptors, three SPECT studies have found no significant changes. MRS studies haveshown decreased levels of NAA (N-acetyl-aspartate) moieties in hippocampusand frontal cortex of schizophrenic patients, which is consistent with thereported loss of neurons and neuropil in postmortem brains. In conclusion,developments in radiotracer and NMR imaging have provided promising leads to the biochemical abnormalities associated with schizophrenia. Future significant understanding is likely to occur with the development of new probesand enhanced instrument technology, when applied with an appreciation of the heterogeneity of the disorder and the need for careful clinical assessment of patients. Biol Psychiatry 1999;46:600-615 (C) 1999 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 11:10:17