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Titolo:
The macromolecular characteristics of cartilage proteoglycans do not change when synthesis is up-regulated by link protein peptide
Autore:
Liu, HX; McKenna, LA; Dean, MF;
Indirizzi:
Univ London Royal Vet Coll, Dept Vet Basic Sci, London NW1 0TU, England Univ London Royal Vet Coll London England NW1 0TU ondon NW1 0TU, England Univ Erlangen Nurnberg, Inst Pathol, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
fascicolo: 2-3, volume: 1428, anno: 1999,
pagine: 191 - 200
SICI:
0304-4165(19990805)1428:2-3<191:TMCOCP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ARTICULAR-CARTILAGE; FIBRONECTIN FRAGMENTS; HYALURONIC-ACID; CORE PROTEIN; EXTRACELLULAR-MATRIX; B-CELLS; CHONDROCYTES; BINDING; TISSUE; AGE;
Keywords:
link protein peptide; cartilage culture; proteoglycan;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Dean, MF Univ London Royal Vet Coll, Dept Vet Basic Sci, Royal Coll St, London NW1 0TU, England Univ London Royal Vet Coll Royal Coll St London England NW1 0TU
Citazione:
H.X. Liu et al., "The macromolecular characteristics of cartilage proteoglycans do not change when synthesis is up-regulated by link protein peptide", BBA-GEN SUB, 1428(2-3), 1999, pp. 191-200

Abstract

Previous studies have shown that a synthetic, unglycosylated analogue of the N-terminal peptide from link protein can function as a growth factor andup-regulate proteoglycan biosynthesis in explant cultures of normal human articular cartilage from a wide age range of subjects (McKenna et al., Arthritis Rheum. 41 (1998) 157-162). The present work further shows that link peptide increased proteoglycan synthesis by cartilage cultured in both the presence and absence of serum, suggesting that the mechanism of up-regulation may be different from that of insulin-like growth factors. The proteoglycans synthesised during stimulation with link peptide were of normal hydrodynamic size and the ratio of core protein to glycosaminoglycan side chains and the proportions of the large proteoglycan aggrecan to the small proteoglycans, decorin and biglycan, remained constant. Aggrecan molecules were equally capable of forming aggregates as those from control tissues and the relative proportions of decorin and biglycan were unchanged showing that bothwere co-ordinately upregulated. These results confirmed that this novel peptide is a potent stimulator of proteoglycan synthesis by articular cartilage and showed that the newly synthesised proteoglycans were of normal composition. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 16:09:59