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Titolo:
The effects of pulsatile versus nonpulsatile perfusion on blood viscoelasticity before and after deep hypothermic circulatory arrest in a neonatal piglet model
Autore:
Undar, A; Henderson, N; Thurston, GB; Masai, T; Beyer, EA; Frazier, OH; Fraser, CD;
Indirizzi:
Texas Childrens Hosp, Houston, TX 77030 USA Texas Childrens Hosp Houston TX USA 77030 ens Hosp, Houston, TX 77030 USA Texas Heart Inst, Cullen Cardiovasc Surg Res Labs, Houston, TX 77025 USA Texas Heart Inst Houston TX USA 77025 urg Res Labs, Houston, TX 77025 USA Baylor Coll Med, Dept Surg, Houston, TX 77030 USA Baylor Coll Med HoustonTX USA 77030 ed, Dept Surg, Houston, TX 77030 USA Univ Texas, Dept Mech & Biomed Engn, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 t Mech & Biomed Engn, Austin, TX 78712 USA Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 , Dept Pediat, Houston, TX 77030 USA
Titolo Testata:
ARTIFICIAL ORGANS
fascicolo: 8, volume: 23, anno: 1999,
pagine: 717 - 721
SICI:
0160-564X(199908)23:8<717:TEOPVN>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOPULMONARY BYPASS SYSTEM; FLOW; INFANT;
Keywords:
blood viscoelasticity; pulsatile flow; blood trauma; cardiopulmonary bypass; deep hypothermic circulatory arrest;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Undar, A Texas Childrens Hosp, 6621 Fannin St,MC 1-2285, Houston, TX 77030USA Texas Childrens Hosp 6621 Fannin St,MC 1-2285 Houston TX USA 77030
Citazione:
A. Undar et al., "The effects of pulsatile versus nonpulsatile perfusion on blood viscoelasticity before and after deep hypothermic circulatory arrest in a neonatal piglet model", ARTIF ORGAN, 23(8), 1999, pp. 717-721

Abstract

Blood trauma increases blood viscoelasticity by increasing red cell aggregation and plasma viscosity and by decreasing cell deformability. During extracorporeal circulation, the mode of perfusion (pulsatile or nonpulsatile) may have a significant impact on blood trauma. In this study, a hydraulically driven dual chamber pulsatile pump system was compared to a standard nonpulsatile roller pump in terms of changes in the blood viscosity and elasticity during cardiopulmonary bypass (CPB) and pre and post deep hypothermic circulatory arrest (DHCA). Piglets, with an average weight of 3 kg, were used in the pulsatile (n = 5) or nonpulsatile group (n = 5). All animals weresubjected to 25 min of hypothermia, 60 min of DHCA, 10 min of cold reperfusion, and 40 min of rewarming with a pump flow of 150 ml/kg/min. A pump rate of 150 bpm, pump ejection time of 120 ms, and stroke volume of 1 ml/kg were used during pulsatile CPB. Arterial blood samples were taken pre-CPB (36degrees C), during normothermic CPB (35 degrees C), during hypothermic CPB(25 degrees C), pre-DHCA (18 degrees C), post-DHCA (19 degrees C), post-rewarming (35 degrees C), and post-CPB (36 degrees C). Viscosity and elasticity were measured at 2 Hz and 22 degrees C and at strains of 0.2, 1, and 5 using the Vilastic-3 Viscoelasticity Analyzer. Results suggest that the dualchamber neonate-infant pulsatile pump system produces less blood trauma than the standard nonpulsatile roller pump as indicated by lower values of both viscosity and elasticity during CPB support.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/12/18 alle ore 23:43:30