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Titolo:
Release of renal dipeptidase from rabbit renal proximal tubules and its inhibition by gentamicin
Autore:
Kang, BY; We, JS; Choi, K; Lee, HB; Han, HJ; Park, HS;
Indirizzi:
Chonnam Natl Univ, Coll Pharm, Dept Pharm, Kwangju 500757, South Korea Chonnam Natl Univ Kwangju South Korea 500757 Kwangju 500757, South Korea Chonnam Natl Univ, Coll Nat Sci, Dept Biol, Kwangju 500757, South Korea Chonnam Natl Univ Kwangju South Korea 500757 Kwangju 500757, South Korea Chonnam Natl Univ, Coll Vet Med, Dept Vet Physiol, Kwangju 500757, South Korea Chonnam Natl Univ Kwangju South Korea 500757 Kwangju 500757, South Korea
Titolo Testata:
ARCHIVES OF PHARMACAL RESEARCH
fascicolo: 4, volume: 22, anno: 1999,
pagine: 367 - 371
SICI:
0253-6269(199908)22:4<367:RORDFR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
KIDNEY MICROVILLAR MEMBRANE; PHOSPHOLIPASE-C; AMINOGLYCOSIDE NEPHROTOXICITY; CISPLATIN NEPHROTOXICITY; AFFINITY PURIFICATION; ECTO-ENZYMES; FORM; MECHANISMS; INSIGHTS; ANCHOR;
Keywords:
proximal tubule; glycosylphosphatidylinositol (GPI)-protein; renal dipeptidase (RDPase); phosphatidylinositol specific phospholipase C (PI-PLC); gentamicin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Park, HS Chonnam Natl Univ, Coll Pharm, Dept Pharm, Kwangju 500757, South Korea Chonnam Natl Univ Kwangju South Korea 500757 00757, South Korea
Citazione:
B.Y. Kang et al., "Release of renal dipeptidase from rabbit renal proximal tubules and its inhibition by gentamicin", ARCH PH RES, 22(4), 1999, pp. 367-371

Abstract

Effects of several drugs on rabbit renal proximal tubules were examined for the applicability of renal dipeptidase (RDPase, EC 3. 4. 13. 11) release as a model system to study nephrotoxicity. The proximal tubule prepared by the method of Taub (1990) released RDPase spontaneously in the control experiment which was confirmed by Western blotting. RDPase was also released from cisplatin, lipopolysaccharide (LPS), and indomethacin-treated tubules. Gentamicin inhibited RDPase release in a concentration-dependent manner. This RDPase release system may not be a general model to screen nephrotoxicitybut could be a useful source of RDPase purification in a simple and inexpensive way.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 05:59:44