Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Induction by tumour necrosis factor alpha of dose-related changes in Langerhans cell frequency in mice
Autore:
Cumberbatch, M; Dearman, RJ; Kimber, I;
Indirizzi:
Astra Zeneca Cent Toxicol Lab, Macclesfield SK10 4TJ, Cheshire, England Astra Zeneca Cent Toxicol Lab Macclesfield Cheshire England SK10 4TJ land
Titolo Testata:
ARCHIVES OF DERMATOLOGICAL RESEARCH
fascicolo: 7-8, volume: 291, anno: 1999,
pagine: 453 - 458
SICI:
0340-3696(199907/08)291:7-8<453:IBTNFA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION MOLECULE EXPRESSION; DRAINING LYMPH-NODES; DENDRITIC CELLS; CONTACT SENSITIZATION; MIGRATION; INTERLEUKIN-1-BETA; CYTOKINES; ALLERGENS;
Keywords:
Langerhans cell; dendritic cell; tumour necrosis factor alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Cumberbatch, M Astra Zeneca Cent Toxicol Lab, Alderley Pk, Macclesfield SK10 4TJ, Cheshire, England Astra Zeneca Cent Toxicol Lab Alderley Pk Macclesfield Cheshire England SK10 4TJ
Citazione:
M. Cumberbatch et al., "Induction by tumour necrosis factor alpha of dose-related changes in Langerhans cell frequency in mice", ARCH DERM R, 291(7-8), 1999, pp. 453-458

Abstract

It has been demonstrated previously that tumour necrosis factor alpha (TNF-alpha) provides an important signal for the migration of epidermal Langerhans cells (LC) from the skin. Intradermal administration to mice of homologous recombinant TNF-alpha induces both a rapid reduction in the frequency of LC local to the site of exposure and, somewhat later, an accumulation of dendritic cells in draining lymph nodes. It has been proposed recently, however, that the influence of TNF-alpha on LC function may be dose-dependent in nature with lower concentrations inducing migration, but higher concentrations immobilizing LC in the epidermis. To investigate this proposal we examined the kinetics and dose-response relationships of TNF-alpha-induced LCmigration in mice. At all concentrations tested (50, 150 or 300 ng/ear), intradermal exposure to TNF-alpha caused within 30 min a significant reduction in the frequency of MHC class II (Ia)(+) LC within epidermal sheets. With the lower concentrations of TNF-alpha this effect was still apparent whenLC were enumerated in the epidermis up to 4 h following cytokine treatment. In contrast, however, exposure of mice to 300 ng of TNF-alpha was consistently associated with a considerably less marked, and statistically insignificant, reduction in LC frequency by 4 h. These data indicate that at all concentrations of the cytokine examined here, TNF-alpha was able to stimulate a rapid (within 30 min) reduction in epidermal LC numbers, but that the rapidity with which the epidermis was repopulated following the initiation of LC migration was influenced by the concentration of TNF-alpha administered. It is suggested that TNF-alpha may influence not only the tempo of LC migration, but also the kinetics of epidermal repopulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:21:04