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Titolo:
ENX (HOX11L1)-DEFICIENT MICE DEVELOP MYENTERIC NEURONAL HYPERPLASIA AND MEGACOLON
Autore:
SHIRASAWA S; YUNKER AMR; ROTH KA; BROWN GA; HORNING S; KORSMEYER SJ;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT MED,HOWARD HUGHES MED INST,DIV MOL ONCOL,660 S EUCLID,BOX 8022 ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT MED,HOWARD HUGHES MED INST,DIV MOL ONCOLST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PATHOL ST LOUIS MO 63110
Titolo Testata:
Nature medicine
fascicolo: 6, volume: 3, anno: 1997,
pagine: 646 - 650
SICI:
1078-8956(1997)3:6<646:E(MDMN>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENTERIC NERVOUS-SYSTEM; ENDOTHELIN-B RECEPTOR; NITRIC-OXIDE SYNTHASE; HIRSCHSPRUNGS-DISEASE; INTESTINAL DYSPLASIA; NADPH DIAPHORASE; TRANSGENIC MICE; HOX11 GENE; GUINEA-PIG; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
S. Shirasawa et al., "ENX (HOX11L1)-DEFICIENT MICE DEVELOP MYENTERIC NEURONAL HYPERPLASIA AND MEGACOLON", Nature medicine, 3(6), 1997, pp. 646-650

Abstract

The isolated homeobox gene Enx (Hox11L1) is expressed in enteric neurons Innervating distal ileum, and proximal and distal colon. Enx-deficient mice develop megacolon with massive distension of the proximal colon. The number of myenteric ganglia, total neurons per ganglion, and NADPH diaphorase presumptive inhibitory neurons per ganglion are increased in the proximal and distal colon, but decreased in the distal ileum of all Enx(-/-) mice. Enx(-/-) mice provide a model for human neuronal intestinal dysplasia (NID), in which myenteric neuronal hyperplasia and megacolon are seen. These results suggest that Enx is required for the proper positional specification and differentiative cell fate of enteric neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 11:15:46