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Titolo:
Options for managing psychotropic medications in drug-abusing patients participating in behavioral therapies clinical trials
Autore:
Rounsaville, BJ; Weiss, R; Carroll, K;
Indirizzi:
Yale Univ, Sch Med, CMHC, Dept Psychiat, New Haven, CT 06519 USA Yale Univ New Haven CT USA 06519 , Dept Psychiat, New Haven, CT 06519 USA McLean Hosp, Alcohol & Drug Abuse Treatment Program, Belmont, MA 02178 USAMcLean Hosp Belmont MA USA 02178 Treatment Program, Belmont, MA 02178 USA
Titolo Testata:
AMERICAN JOURNAL ON ADDICTIONS
fascicolo: 3, volume: 8, anno: 1999,
pagine: 178 - 189
SICI:
1055-0496(199922)8:3<178:OFMPMI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; SUBSTANCE USE DISORDER; IMIPRAMINE TREATMENT; ALCOHOL DEPENDENCE; COCAINE ABUSERS; PSYCHIATRIC-DISORDERS; NONRANDOM ASSIGNMENT; MAJOR DEPRESSION; MENTAL-DISORDERS; DOUBLE-BLIND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Rounsaville, BJ Yale Univ, Sch Med, CMHC, Dept Psychiat, 34 Pk St,Rm S202,New Haven, CT 06519 USA Yale Univ 34 Pk St,Rm S202 New Haven CT USA 06519 6519 USA
Citazione:
B.J. Rounsaville et al., "Options for managing psychotropic medications in drug-abusing patients participating in behavioral therapies clinical trials", AM J ADDICT, 8(3), 1999, pp. 178-189

Abstract

This manuscript reviews strengths and weaknesses of common design options for managing non-study medications in randomized clinical trials of behavioral treatments fbr drug abusers. While the principal focus of these trials is on the relative efficacy of different behavioral interventions, drug abusers entering these trials are often either using or in need of prescribed psychotropic medications which can have a major independent impact on treatment outcome. Options reviewed range from tight to minimal restriction on use of ancillary medications. Generally major tradeoffs pertain to the balance between internal validity and generalizability. However, experimental rigor cml be maintained while allowing subjects to use ancillary medications if steps are taken to monitor and minimize the variability in treatment delivery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:16:49