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Titolo:
Wheat allergy: diagnostic accuracy of skin prick and patch tests and specific IgE
Autore:
Majamaa, H; Moisio, P; Holm, K; Turjanmaa, K;
Indirizzi:
Tampere Univ, Sch Med, FIN-33101 Tampere, Finland Tampere Univ Tampere Finland FIN-33101 h Med, FIN-33101 Tampere, Finland Tampere Univ Hosp, Dept Dermatol, Tampere, Finland Tampere Univ Hosp Tampere Finland Hosp, Dept Dermatol, Tampere, Finland Tampere Univ Hosp, Dept Pediat, Tampere, Finland Tampere Univ Hosp Tampere Finland v Hosp, Dept Pediat, Tampere, Finland
Titolo Testata:
ALLERGY
fascicolo: 8, volume: 54, anno: 1999,
pagine: 851 - 856
SICI:
0105-4538(199908)54:8<851:WADAOS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
COW MILK ALLERGY; ATOPIC-DERMATITIS; FOOD ALLERGY; CHILDREN; HYPERSENSITIVITY; INFANTS; REACTIVITY; CEREALS; ECZEMA;
Keywords:
atopic eczema; cereal allergy; food challenge; patch test; skin prick test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Majamaa, H Tampere Univ, Sch Med, POB 607, FIN-33101 Tampere, Finland Tampere Univ POB 607 Tampere Finland FIN-33101 ampere, Finland
Citazione:
H. Majamaa et al., "Wheat allergy: diagnostic accuracy of skin prick and patch tests and specific IgE", ALLERGY, 54(8), 1999, pp. 851-856

Abstract

Background: Food allergy makes an important contribution to the pathogenesis of atopic eczema in infants. However, clinical data on cereal allergy are scanty. The objective was to study the relevance of patch testing, skin prick tests, and the concentration of wheat-specific IgE antibodies (CAP RAST) in correlation with oral wheat challenge in infants with suspected wheatallergy. In particular, we aimed to determine whether the patch test couldincrease the diagnostic accuracy in detecting wheat allergy. Methods: The study material comprised 39 infants under the age of 2 years. Of these patients, 36 were suffering from atopic eczema and three had onlygastrointestinal symptoms. The patients were subjected to a double-blind, placebo-controlled or open wheat challenge. Wheat-specific IgE was measuredby CAP RAST, and skin prick and patch tests were performed. Results: Of the total 39 wheat challenges, 22 (56%) were positive. Of the positive reactions, five involved immediate-type skin reactions over a period of 2 h from the commencement of the challenge. In 17 patients, delayed-onset reactions of eczematous or gastrointestinal type appeared. Of the infants with challenge-proven wheat allergy, 20% showed elevated IgE concentrations to wheat, 23% had a positive skin prick test, and 86% had a positive patch test for wheat. The specificities of CAP RAST, skin prick tests, and patch tests were 0.93, 1.00, and 0.35, respectively. Conclusions: Our study demonstrated that patch testing with cereals will significantly increase the probability of early detection of cereal allergy in infants with atopic eczema and is helpful in the planning of successful elimination diets before challenge. The specificity of the patch test was lower than that of other tests. Therefore, confirmation of the diagnosis with the elimination-challenge test is essential in patients with positive patch test results.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:34:30