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Titolo:
The patch test, skin prick test, and serum milk-specific IgE as diagnostictools in cow's milk allergy in infants
Autore:
Vanto, T; Juntunen-Backman, K; Kalimo, K; Klemola, T; Koivikko, A; Koskinen, P; Syvanen, P; Valovirta, E; Varjonen, E;
Indirizzi:
Turku Univ Hosp, Dept Pediat, FIN-20520 Turku, Finland Turku Univ Hosp Turku Finland FIN-20520 Pediat, FIN-20520 Turku, Finland Univ Helsinki, Cent Hosp, Skin & Allergy Hosp, Dept Allergol, Helsinki, Finland Univ Helsinki Helsinki Finland y Hosp, Dept Allergol, Helsinki, Finland Turku Univ Hosp, Dept Dermatol, FIN-20520 Turku, Finland Turku Univ Hosp Turku Finland FIN-20520 rmatol, FIN-20520 Turku, Finland Turku Univ Hosp, Cent Lab, FIN-20520 Turku, Finland Turku Univ Hosp Turku Finland FIN-20520 nt Lab, FIN-20520 Turku, Finland
Titolo Testata:
ALLERGY
fascicolo: 8, volume: 54, anno: 1999,
pagine: 837 - 842
SICI:
0105-4538(199908)54:8<837:TPTSPT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATOPIC-DERMATITIS; FOOD CHALLENGES; DOUBLE-BLIND;
Keywords:
cow's milk allergy; IgE; patch test; ROC curve; skin prick test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Vanto, T Turku Univ Hosp, Dept Pediat, FIN-20520 Turku, Finland Turku UnivHosp Turku Finland FIN-20520 IN-20520 Turku, Finland
Citazione:
T. Vanto et al., "The patch test, skin prick test, and serum milk-specific IgE as diagnostictools in cow's milk allergy in infants", ALLERGY, 54(8), 1999, pp. 837-842

Abstract

We evaluated the value of the patch test, skin prick test, and milk-specific IgE by CAP RAST in 301 infants with suspected hypersensitivity to cow's milk. The patch test was carried out with milk powder, and the skin prick test with cow's milk-based formula. Hypersensitivity to cow's milk was determined with double-blind, placebo-controlled challenge. An immediate reaction to cow's milk challenge was observed in 100 infants (33%), a delayed reaction in 76 (25%), and a negative result in 125 (42%). Skin prick test wheals were significantly greater in infants with immediate reactions than in infants with delayed or negative reactions. Milk-specific IgE was correlated with the skin prick test (r=0.78, P<0.001, n=268) but did not contribute tofurther discrimination of immediate reactions from delayed or negative reactions compared to skin prick test alone. In our study population, the skinprick test (diameter greater than or equal to 3 mm) showed a specificity and sensitivity of 91% and 69%; the results for milk-specific IgE (greater than or equal to 0.7 kU/I) were 88% and 58%, respectively. The patch test did not distinguish subjects with immediate or delayed reactions from those with negative reactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:37:20