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Titolo:
Pharyngeal pituitary: development, malformation, and tumorigenesis
Autore:
Hori, A; Schmidt, D; Rickels, E;
Indirizzi:
Med Hsch Hannover, Inst Neuropathol, D-30623 Hannover, Germany Med Hsch Hannover Hannover Germany D-30623 ol, D-30623 Hannover, Germany Agnes Karll Hosp, Laatzen Hannover, Germany Agnes Karll Hosp Laatzen Hannover Germany sp, Laatzen Hannover, Germany Med Hsch Hannover, Dept Neurosurg, Hannover, Germany Med Hsch Hannover Hannover Germany r, Dept Neurosurg, Hannover, Germany
Titolo Testata:
ACTA NEUROPATHOLOGICA
fascicolo: 3, volume: 98, anno: 1999,
pagine: 262 - 272
SICI:
0001-6322(199909)98:3<262:PPDMAT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPHENOID SINUS; CUSHINGS-DISEASE; ECTOPIC PROLACTINOMA; SELLA TURCICA; ADENOMA; TUMOR; PATIENT; GLAND; ADENOHYPOPHYSIS; FETUSES;
Keywords:
development of pituitary gland; ectopic pituitary adenoma; pharyngeal pituitary; pituitary hormone; pituitary malformation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Hori, A Med Hsch Hannover, Inst Neuropathol, D-30623 Hannover, Germany MedHsch Hannover Hannover Germany D-30623 623 Hannover, Germany
Citazione:
A. Hori et al., "Pharyngeal pituitary: development, malformation, and tumorigenesis", ACT NEUROP, 98(3), 1999, pp. 262-272

Abstract

The development of the pharyngeal pituitary (PhP) in the fetal period was morphologically and, for the first time, immunohistochemically examined. PhP, found in every individual, begins its hormone production at the 17-18th week of gestation, that is, 4-8 weeks later than that of sellar pituitary (SP). Only 1 of 25 examined fetuses without any stigmata of developmental anomalies showed a residual pituitary fragment in the craniopharyngeal canal (craniopharyngeal pituitary, CPhP). An adult case of a rare clivus pituitary adenoma that we examined is demonstrated in discussing its relationship to PhP. Extracranial ectopic pituitary adenomas in the literature describe an exclusively sphenoid sinus/nasopharyngeal/clivus location of the tumor. Their location corresponded exactly with that of PhP, so that the origin of the tumors can be reasonably speculated as PhP, although another origin, e.g., CPhP, can not be excluded. A variety of malformations of PhP, although very rare, have been described for the fist Lime during the systemic examination of 16 fetuses with different cranioneural malformations, such as agenesis, unseparated PhP from SP (pharyngosellar pituitary), fragmentation, and residual pituitary tissue in the open craniopharyngeal canal. However, developmental anomaly of PhP was not specifically associated with cranioneural malformations except in cases of chromosomal aberrations. The hormone production in PhP in malformation cases tended to be retarded. Absence of SP was recorded in 50% of anencephalics in the literature; however, PhP was identified in all anencephalics in our series, independent of the existence ofSP. This supports the opinion that agenesis of SP in anencephalics seems to be false information.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 02:06:51