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Titolo:
Relationship of ECL cells and gastric neoplasia
Autore:
Waldum, HL; Brenna, E; Sandvik, AK;
Indirizzi:
Univ Trondheim Hosp, Dept Med, N-7006 Trondheim, Norway Univ Trondheim Hosp Trondheim Norway N-7006 ed, N-7006 Trondheim, Norway
Titolo Testata:
YALE JOURNAL OF BIOLOGY AND MEDICINE
fascicolo: 3-4, volume: 71, anno: 1998,
pagine: 325 - 335
SICI:
0044-0086(199805/08)71:3-4<325:ROECAG>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENTEROCHROMAFFIN-LIKE CELLS; PEROXISOME-PROLIFERATOR CIPROFIBRATE; HUMAN GASTROINTESTINAL-TRACT; ZOLLINGER-ELLISON SYNDROME; FIBROBLAST GROWTH-FACTOR; PERFUSED RAT STOMACH; ENDOCRINE-CELLS; OXYNTIC MUCOSA; CARCINOID-TUMORS; ALPHA-FLUOROMETHYLHISTIDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Waldum, HL Univ Trondheim Hosp, Dept Med, N-7006 Trondheim, Norway Univ Trondheim Hosp Trondheim Norway N-7006 Trondheim, Norway
Citazione:
H.L. Waldum et al., "Relationship of ECL cells and gastric neoplasia", YALE J BIOL, 71(3-4), 1998, pp. 325-335

Abstract

The enterochromaffin-like (ECL) cell in the oxyntic mucosa has a key role in the regulation of gastric secretion since it synthesizes and releases the histamine regulating the acid secretion from the parietal cell. Gastrin is the main regulator of the ECL cell function and growth. Long-term hypergastrinemia induces ECL cell hyperplasia, and if continued, neoplasia. ECL cell carcinoids occur in man after long-term hypergastrinemia in conditions like pernicious anemia and gastrinoma. There is also accumulating evidence that a proportion of gastric carcinomas of the diffuse type is derived from the ECL cell. Furthermore, the ECL cell may, by producing substances with angiogenic effects (histamine and basic fibroblast growth factor), be particularly prone to develop malignant tumors. Although the general opinion is that gastrin itself has a direct effect on the oxyntic mucosal stem cell, itcannot be excluded that the general trophic effect of gastrin on the oxyntic mucosa is mediated by histamine or other substances from the ECL cell, and that the ECL cell, therefore, could play a role also in the tumorigenesis/carcinogenesis of gastric carcinomas of intestinal type.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:09:38