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Titolo:
Paracrine neurotransmission in the CNS: involvement of 5-HT
Autore:
Bunin, MA; Wightman, RM;
Indirizzi:
Univ N Carolina, Dept Chem & Neurobiol Curriculum, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 culum, Chapel Hill, NC 27599 USA
Titolo Testata:
TRENDS IN NEUROSCIENCES
fascicolo: 9, volume: 22, anno: 1999,
pagine: 377 - 382
SICI:
0166-2236(199909)22:9<377:PNITCI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL INHIBITORY SYNAPSE; CEREBELLAR PURKINJE-CELLS; REAL-TIME MEASUREMENT; RAT-BRAIN; DORSAL RAPHE; GLUTAMATE TRANSPORTERS; ASTROCYTIC PROCESSES; TRANSMITTER RELEASE; NUCLEUS-ACCUMBENS; SUBSTANTIA-NIGRA;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Bunin, MA Univ N Carolina, Dept Chem & Neurobiol Curriculum, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 pel Hill, NC 27599 USA
Citazione:
M.A. Bunin e R.M. Wightman, "Paracrine neurotransmission in the CNS: involvement of 5-HT", TRENDS NEUR, 22(9), 1999, pp. 377-382

Abstract

While GABA and glutamate have an established synaptic function in the CNS,recent evidence suggests 5-HT neurotransmission is predominantly paracrine. As the amino-acid neurotransmitters interact with receptors that produce effects rapidly, electrophysiological approaches can be used to assess the time delay between transmitter release and the postsynaptic response directly However, this approach cannot be used for studies of 5-HT-mediated neurotransmission, because the majority of its receptors react more slowly, so anatomical and voltammetrical approaches have been used to provide insight into 5-HT-mediated events. These studies have revealed that extrasynaptic receptors and transporters for 5-HT exist, and that 5-HT escapes readily fromthe synaptic cleft. Attenuation of 5-HT binding by 5-HT-receptor antagonists and 5-HT-uptake inhibitors does not affect the synaptic efflux elicited by transient stimuli, although the effects of such drugs are apparent at later time points. Once it is extrasynaptic, 5-HT has a concentration that issimilar to those estimated to be optimal for receptor and transporter activation, and it can diffuse a few micrometers until removed by its transporter. These properties of 5-HT raise the possibility that it can act on receptors that are distant from its release site and function as a paracrine transmitter.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 15:00:45