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Titolo:
Improved preservation solutions for organ storage - A dynamic study of hepatic metabolism
Autore:
Changani, KK; Fuller, BJ; Bell, JD; Taylor-Robinson, SD; Moore, DP; Davidson, BR;
Indirizzi:
Hammersmith Hosp, Imperial Coll, Sch Med, Div Med,MRC,MR Unit, London W12 0NN, England Hammersmith Hosp London England W12 0NN MR Unit, London W12 0NN, England Royal Free Hosp & Med Sch, Dept Surg, London NW3 2QG, England Royal Free Hosp & Med Sch London England NW3 2QG London NW3 2QG, England Hammersmith Hosp, Imperial Coll, Sch Med, Div Med,Dept Gastroenterol, London W12 0NN, England Hammersmith Hosp London England W12 0NN enterol, London W12 0NN, England
Titolo Testata:
TRANSPLANTATION
fascicolo: 3, volume: 68, anno: 1999,
pagine: 345 - 355
SICI:
0041-1337(19990815)68:3<345:IPSFOS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENINE-NUCLEOTIDE METABOLISM; RAT-LIVER PRESERVATION; UW-SOLUTION; HYPOTHERMIC REPERFUSION; CANINE LIVER; DONOR LIVER; TRANSPLANTATION; LACTOBIONATE; VIABILITY; EUROCOLLINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Changani, KK Hammersmith Hosp, Imperial Coll, Sch Med, Div Med,MRC,MR Unit, Du Cane Rd,London W12 0NN, England Hammersmith Hosp Du Cane Rd London England W12 0NN , England
Citazione:
K.K. Changani et al., "Improved preservation solutions for organ storage - A dynamic study of hepatic metabolism", TRANSPLANT, 68(3), 1999, pp. 345-355

Abstract

Background. Organ cold storage times may be extended by modifications to organ preservation solutions,Methods. Three preservation solutions were investigated for their ability to maintain viable hepatic bioenergetics in stored pig livers: modified University of Wisconsin (mUW); mUW+adenosine (1.34 g\L), and mUW+iloprost (10(-8)mol/L), a prostacyclin analogue. Using human liver retrieval and storagetechniques, pig livers were stored on ice for either 2 or 16 hr, after which phosphorus-31 spectra were collected every 2 min during the period of cold ischemia and hypothermic reperfusion (HtR), During HtR, metabolite concentration changes associated with phosphomonoesters, inorganic phosphate, gamma-nucleotide triphosphate (NTP), and beta-NTP were measured for all solutions. Results. After a 2-hr storage, beta-NTP regeneration in mUW+iloprost produced +57.7% (P < 0.01) more beta-NTP, at a faster initial rate of +66.3% (P < 0.001), compared with mUW, and mUW+adenosine regenerated +35.6% (P < 0.05) more beta-NTP, compared with mUW. Storage for 16 hr did not slow the rates of regeneration, and the total NTP produced during the course of the experiment remained unchanged for the respective preservation solutions. Cessation of HtR invoked a net accumulation of nucleotide diphosphate, indicatingdifferential kinetics of adenine nucleotide hydrolysis,Conclusion. This large animal model study suggests significant improvements to human organ preservation solutions using prostacyclin analogues and adenosine with respect to hepatic bioenergetics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 02:37:11