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Titolo:
Development of high-performance frontal analysis and the application to the study of drug-plasma protein binding
Autore:
Shibukawa, A; Kuroda, Y; Nakagawa, T;
Indirizzi:
Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 aceut Sci, Sakyo Ku, Kyoto 6068501, Japan
Titolo Testata:
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
fascicolo: 8, volume: 18, anno: 1999,
pagine: 549 - 556
SICI:
0165-9936(199908)18:8<549:DOHFAA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHIC SYSTEM; TOTAL CARBAMAZEPINE CONCENTRATIONS; DIRECT SAMPLE INJECTION; PHASE SILICA SUPPORT; BASIC DRUG; STEREOSELECTIVE DETERMINATION; ALBUMIN SOLUTION; SERUM-ALBUMIN; EQUILIBRIUM; ENANTIOMERS;
Keywords:
drug-plasma protein binding; high-performance frontal analysis stereoselective protein binding; carbamazepine; plasma; enantioselective protein binding;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Shibukawa, A Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501,Japan Kyoto Univ Kyoto Japan 6068501 kyo Ku, Kyoto 6068501, Japan
Citazione:
A. Shibukawa et al., "Development of high-performance frontal analysis and the application to the study of drug-plasma protein binding", TRAC-TREND, 18(8), 1999, pp. 549-556

Abstract

Drug-plasma protein binding is a reversible and kinetically rapid interaction process which should be analyzed without disturbing the binding equilibrium. Till now, equilibrium dialysis and ultrafiltration followed by HPLC have been used to determine the unbound drug concentrations. However, this method involves problems such as drug adsorption onto the membrane and leakage of bound drug. Furthermore, the drug-protein binding equilibrium may deviate due to the change in sample concentration during filtration. To overcome these problems a novel chromatographic method, high-performance frontal analysis (HPFA), was developed. This article describes the principles of HPFA and its applicability to the study of stereoselective protein binding. (C) 1999 Elsevier Science B.V, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:43:07