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Titolo:
The potential role of therapeutic cytokine manipulation in acute pancreatitis
Autore:
Denham, W; Norman, J;
Indirizzi:
Univ S Florida, Coll Med, Dept Surg, Tampa Gen Hosp, Tampa, FL 33601 USA Univ S Florida Tampa FL USA 33601 rg, Tampa Gen Hosp, Tampa, FL 33601 USA Univ S Florida, Coll Med, Dept Surg, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 oll Med, Dept Surg, Tampa, FL 33612 USA Univ S Florida, Coll Med, Dept Internal Med, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 Dept Internal Med, Tampa, FL 33612 USA James A Haley Vet Hosp, Tampa, FL 33612 USA James A Haley Vet Hosp Tampa FL USA 33612 y Vet Hosp, Tampa, FL 33612 USA
Titolo Testata:
SURGICAL CLINICS OF NORTH AMERICA
fascicolo: 4, volume: 79, anno: 1999,
pagine: 767 -
SICI:
0039-6109(199908)79:4<767:TPROTC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-ACTIVATING-FACTOR; TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; ACUTE LUNG INJURY; FACTOR ANTAGONIST; NECROTIZING PANCREATITIS; MACROPHAGE PACIFICATION; SERUM INTERLEUKIN-6; EXPERIMENTAL-MODEL; IMPROVES SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Norman, J Univ S Florida, Coll Med, Dept Surg, Tampa Gen Hosp, Box 1289, Tampa, FL 33601 USA Univ S Florida Box 1289 Tampa FL USA 33601 , Tampa, FL 33601 USA
Citazione:
W. Denham e J. Norman, "The potential role of therapeutic cytokine manipulation in acute pancreatitis", SURG CL NA, 79(4), 1999, pp. 767

Abstract

The central, detrimental role of the inflammatory cytokines, interleukin-land tumor necrosis factor, and the biologically active phospholipid platelet activating factor in the pathogenesis of AP has been established over the past 8 years. Many antagonists to these mediators have been used successfully in the laboratory setting, and are currently being examined in prospective randomized trials. The effectiveness of any antagonist depends not only on its ability to block a particular inflammatory mediator or mediators but also on its administration early in the course of the pancreatitis before pancreatic necrosis or organ dysfunction occur.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 14:15:09