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Titolo:
Transmission of a minor variant of transcriptionally active HIV-1
Autore:
Machuca, R; Schonning, K; Hansen, JES; Bruun, L; Fomsgaard, A; Nielsen, C;
Indirizzi:
Statens Serum Inst, Dept Virol, Retrovirus Lab, DK-2300 Copenhagen, Denmark Statens Serum Inst Copenhagen Denmark DK-2300 K-2300 Copenhagen, Denmark Hvidovre Hosp, Dept Infect Dis, Copenhagen, Denmark Hvidovre Hosp Copenhagen Denmark , Dept Infect Dis, Copenhagen, Denmark
Titolo Testata:
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
fascicolo: 3, volume: 31, anno: 1999,
pagine: 243 - 249
SICI:
0036-5548(1999)31:3<243:TOAMVO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; NEUTRALIZING ANTIBODIES; SEQUENCE HETEROGENEITY; ENVELOPE GLYCOPROTEIN; PRIMARY INFECTION; PLASMA; DOMAIN; EVOLUTION; SELECTION; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Machuca, R Statens Serum Inst, Dept Virol, Retrovirus Lab, Artillerivej 5,DK-2300 Copenhagen, Denmark Statens Serum Inst Artillerivej 5 Copenhagen Denmark DK-2300 k
Citazione:
R. Machuca et al., "Transmission of a minor variant of transcriptionally active HIV-1", SC J IN DIS, 31(3), 1999, pp. 243-249

Abstract

We investigated the genotypic variation of pro-viral human immunodeficiency virus type 1 (HIV-1) DNA in a virus donor-recipient pair by comparing sequences from the HIV-1 V3 region of the gp120 gene and the p17(gag) gene. Wefound that the transmitted virus was a minor variant in the donor's virus population in blood. Possible selection mechanisms within the host (neutralization by antibodies) were studied in order to investigate whether antibodies could explain the conserved HIV genotype found in the recipient. In conclusion, our data indicate that a minor variant of pro-viral transcriptionally active HIV-1 found in PBMC was transmitted from donor to recipient, Development of a homogeneous genotype regarding the V3 region (V3d-Bl(1)) of pro-viral DNA in the recipient's PBMC and a partially homogeneous genotype regarding the HIV-RNA was possibly caused by an envelope associated selection that is not dependent upon neutralizing antibodies.

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Documento generato il 24/11/20 alle ore 14:20:32